Optimization of the extraction procedure for the determination of phenolic acids and flavonoids in the leaves of globe artichoke (Cynara cardunculus var. scolymus L.)

J Pharm Biomed Anal. 2020 Jan 5:177:112879. doi: 10.1016/j.jpba.2019.112879. Epub 2019 Sep 10.

Abstract

Globe artichoke (Cynara cardunculus var. scolymus L.) is not only used as a vegetable and ornamental plant, but also as important medicinal plant for the treatment of dyspeptic disorders. The European Pharmacopoeia describes a method for the quality assessment of dry artichoke leaves, which is time-consuming and requires huge amounts of organic solvents. In this study, an ultrasound-assisted extraction method was studied, which proved to be more efficient than the standard protocol of the European Pharmacopoeia, since it led to comparable results, was faster and easier to handle, and was more sustainable due to a reduced need for organic solvents.

Keywords: Artichoke leaf extracts; European Pharmacopoeia; Hot water extraction; Sonication.

MeSH terms

  • Chemical Fractionation / instrumentation
  • Chemical Fractionation / methods*
  • Chemistry, Pharmaceutical / instrumentation
  • Chemistry, Pharmaceutical / methods
  • Cynara scolymus / chemistry*
  • Feasibility Studies
  • Flavonoids / isolation & purification*
  • Hydroxybenzoates / isolation & purification*
  • Methanol / chemistry
  • Plant Extracts / analysis*
  • Plant Extracts / chemistry
  • Plant Leaves / chemistry
  • Solvents / chemistry
  • Sonication
  • Water / chemistry

Substances

  • Flavonoids
  • Hydroxybenzoates
  • Plant Extracts
  • Solvents
  • Water
  • phenolic acid
  • Methanol