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Showing results for beijing da
Search for Beining Dai instead (3 results)
Next-generation GRAB sensors for monitoring dopaminergic activity in vivo.
Sun F, Zhou J, Dai B, Qian T, Zeng J, Li X, Zhuo Y, Zhang Y, Wang Y, Qian C, Tan K, Feng J, Dong H, Lin D, Cui G, Li Y. Sun F, et al. Nat Methods. 2020 Nov;17(11):1156-1166. doi: 10.1038/s41592-020-00981-9. Epub 2020 Oct 21. Nat Methods. 2020. PMID: 33087905 Free PMC article.
We therefore developed red fluorescent G-protein-coupled receptor-activation-based DA (GRAB(DA)) sensors and optimized versions of green fluorescent GRAB(DA) sensors. ...Moreover, the GRAB(DA) sensors resolve evoked DA release in mouse brain sli …
We therefore developed red fluorescent G-protein-coupled receptor-activation-based DA (GRAB(DA)) sensors and optimized version …
A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice.
Sun F, Zeng J, Jing M, Zhou J, Feng J, Owen SF, Luo Y, Li F, Wang H, Yamaguchi T, Yong Z, Gao Y, Peng W, Wang L, Zhang S, Du J, Lin D, Xu M, Kreitzer AC, Cui G, Li Y. Sun F, et al. Cell. 2018 Jul 12;174(2):481-496.e19. doi: 10.1016/j.cell.2018.06.042. Cell. 2018. PMID: 30007419 Free PMC article.
GRAB(DA) sensors can resolve a single-electrical-stimulus-evoked DA release in mouse brain slices and detect endogenous DA release in living flies, fish, and mice. In freely behaving mice, GRAB(DA) sensors readily report optogenetically elicited nigros …
GRAB(DA) sensors can resolve a single-electrical-stimulus-evoked DA release in mouse brain slices and detect endogenous DA …
Responses and functions of dopamine in nucleus accumbens core during social behaviors.
Dai B, Sun F, Tong X, Ding Y, Kuang A, Osakada T, Li Y, Lin D. Dai B, et al. Cell Rep. 2022 Aug 23;40(8):111246. doi: 10.1016/j.celrep.2022.111246. Cell Rep. 2022. PMID: 36001967 Free PMC article.
Here, we use a genetically encoded DA sensor, GRAB(DA2m), to record DA activity in the nucleus accumbens (NAc) core during various social behaviors in male and female mice. ...Positive and negative social experiences evoke opposite DA patterns. Furthermore, …
Here, we use a genetically encoded DA sensor, GRAB(DA2m), to record DA activity in the nucleus accumbens (NAc) core during var …
Intrinsic dopamine and acetylcholine dynamics in the striatum of mice.
Krok AC, Maltese M, Mistry P, Miao X, Li Y, Tritsch NX. Krok AC, et al. Nature. 2023 Sep;621(7979):543-549. doi: 10.1038/s41586-023-05995-9. Epub 2023 Aug 9. Nature. 2023. PMID: 37558873
Pioneering studies established that these salient sensory stimuli briefly interrupt the tonic discharge of neurons that produce the neuromodulators dopamine (DA) and acetylcholine (ACh): midbrain DA neurons (DANs) fire a burst of action potentials that broadly eleva …
Pioneering studies established that these salient sensory stimuli briefly interrupt the tonic discharge of neurons that produce the neuromod …
Human iPSC-derived midbrain organoids functionally integrate into striatum circuits and restore motor function in a mouse model of Parkinson's disease.
Zheng X, Han D, Liu W, Wang X, Pan N, Wang Y, Chen Z. Zheng X, et al. Theranostics. 2023 Apr 29;13(8):2673-2692. doi: 10.7150/thno.80271. eCollection 2023. Theranostics. 2023. PMID: 37215566 Free PMC article.
Rationale: Parkinson's disease (PD) is a prevalent neurodegenerative disorder that is characterized by degeneration of dopaminergic neurons (DA) at the substantia nigra pas compacta (SNpc). Cell therapy has been proposed as a potential treatment option for PD, with the aim …
Rationale: Parkinson's disease (PD) is a prevalent neurodegenerative disorder that is characterized by degeneration of dopaminergic neurons …
Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo.
Zhuo Y, Luo B, Yi X, Dong H, Miao X, Wan J, Williams JT, Campbell MG, Cai R, Qian T, Li F, Weber SJ, Wang L, Li B, Wei Y, Li G, Wang H, Zheng Y, Zhao Y, Wolf ME, Zhu Y, Watabe-Uchida M, Li Y. Zhuo Y, et al. Nat Methods. 2024 Apr;21(4):680-691. doi: 10.1038/s41592-023-02100-w. Epub 2023 Nov 30. Nat Methods. 2024. PMID: 38036855
Dopamine (DA) plays multiple roles in a wide range of physiological and pathological processes via a large network of dopaminergic projections. To dissect the spatiotemporal dynamics of DA release in both dense and sparsely innervated brain regions, we developed a s …
Dopamine (DA) plays multiple roles in a wide range of physiological and pathological processes via a large network of dopaminergic pr …
Past, Present, and Future of Tools for Dopamine Detection.
Zheng Y, Li Y. Zheng Y, et al. Neuroscience. 2023 Aug 10;525:13-25. doi: 10.1016/j.neuroscience.2023.06.025. Epub 2023 Jul 5. Neuroscience. 2023. PMID: 37419404 Review.
Dopamine (DA) is a critical neuromodulator involved in various brain functions. To understand how DA regulates neural circuits and behaviors in the physiological and pathological conditions, it is essential to have tools that enable the direct detection of DA …
Dopamine (DA) is a critical neuromodulator involved in various brain functions. To understand how DA regulates neural circuits …
The Raphe Dopamine System: Roles in Salience Encoding, Memory Expression, and Addiction.
Lin R, Liang J, Luo M. Lin R, et al. Trends Neurosci. 2021 May;44(5):366-377. doi: 10.1016/j.tins.2021.01.002. Epub 2021 Feb 8. Trends Neurosci. 2021. PMID: 33568331 Review.
Dopamine (DA) neurons of the dorsal raphe nucleus (DRN) were traditionally viewed as an extension of the ventral tegmental area (VTA) DA population. While the VTA DA population is known to play important roles in reward processing, emerging evidence now suppo …
Dopamine (DA) neurons of the dorsal raphe nucleus (DRN) were traditionally viewed as an extension of the ventral tegmental area (VTA) …
Neurotoxicity and Underlying Mechanisms of Endogenous Neurotoxins.
Cao Y, Li B, Ismail N, Smith K, Li T, Dai R, Deng Y. Cao Y, et al. Int J Mol Sci. 2021 Nov 26;22(23):12805. doi: 10.3390/ijms222312805. Int J Mol Sci. 2021. PMID: 34884606 Free PMC article. Review.
An abnormal metabolism of endogenous substances, such as condensation of bioamines with endogenous aldehydes, dopamine (DA) oxidation, and kynurenine pathway, can produce endogenous neurotoxins. ...
An abnormal metabolism of endogenous substances, such as condensation of bioamines with endogenous aldehydes, dopamine (DA) oxidation …
[Source, metabolism and function of dopamine in digestive tract].
Liu CZ, Zhu JX. Liu CZ, et al. Sheng Li Xue Bao. 2020 Jun 25;72(3):336-346. Sheng Li Xue Bao. 2020. PMID: 32572431 Free article. Review. Chinese.
In addition to the synthetases of DA, the DA contents in body tissues are also affected by the two kinds of metabolic enzymes, monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT). This article reviewed the sources, metabolism, and functions of DA …
In addition to the synthetases of DA, the DA contents in body tissues are also affected by the two kinds of metabolic enzymes, …
11,333 results
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