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Year Number of Results
2004 1
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42 results

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Page 1
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain.
Zhou HY, Feng X, Wang LW, Zhou R, Sun H, Chen X, Lu RB, Huang Y, Guo Q, Luo XH. Zhou HY, et al. Cell Metab. 2023 Nov 7;35(11):1915-1930.e8. doi: 10.1016/j.cmet.2023.08.009. Epub 2023 Sep 12. Cell Metab. 2023. PMID: 37703873
These cells, accumulating metabolic memories via epigenetic adaptations, preferentially migrate to the subcutaneous white adipose tissue (WAT), where they secrete fibrinogen-like protein 2 (FGL2) to activate the protein kinase A (PKA) signaling pathway and facilitate beige …
These cells, accumulating metabolic memories via epigenetic adaptations, preferentially migrate to the subcutaneous white adipose tissue (WA …
Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance.
Gong XM, Li YF, Luo J, Wang JQ, Wei J, Wang JQ, Xiao T, Xie C, Hong J, Ning G, Shi XJ, Li BL, Qi W, Song BL. Gong XM, et al. Nat Metab. 2019 May;1(5):570-583. doi: 10.1038/s42255-019-0065-4. Epub 2019 May 6. Nat Metab. 2019. PMID: 32694855
Gpnmb inhibition by a neutralizing antibody or liver-specific knockdown improves metabolic parameters, including weight gain reduction and increased insulin sensitivity, probably by promoting the beiging of WAT. These results suggest that Gpnmb is a liver-secreted factor r …
Gpnmb inhibition by a neutralizing antibody or liver-specific knockdown improves metabolic parameters, including weight gain reduction and i …
Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation.
Quan LH, Zhang C, Dong M, Jiang J, Xu H, Yan C, Liu X, Zhou H, Zhang H, Chen L, Zhong FL, Luo ZB, Lam SM, Shui G, Li D, Jin W. Quan LH, et al. Gut. 2020 Jul;69(7):1239-1247. doi: 10.1136/gutjnl-2019-319114. Epub 2019 Nov 19. Gut. 2020. PMID: 31744910
Our results indicate that E. faecalis and its metabolite MA can reduce adiposity by brown adipose tissue (BAT) activation and beige fat formation. In addition, the gene of E. faecalis encoding Acyl-CoA thioesterases (ACOTs) exhibited the biosynthetic potential to synthesis …
Our results indicate that E. faecalis and its metabolite MA can reduce adiposity by brown adipose tissue (BAT) activation and beige f …
IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice.
Li L, Ma L, Zhao Z, Luo S, Gong B, Li J, Feng J, Zhang H, Qi W, Zhou T, Yang X, Gao G, Yang Z. Li L, et al. PLoS Biol. 2021 Aug 5;19(8):e3001348. doi: 10.1371/journal.pbio.3001348. eCollection 2021 Aug. PLoS Biol. 2021. PMID: 34351905 Free PMC article.
Beige fat dissipates energy and functions as a defense against cold and obesity, but the mechanism for its development is unclear. ...Blockade of IL-4Ralpha or depletion of macrophages with clodronate-loaded liposomes in vivo significantly impaired the beige fat for …
Beige fat dissipates energy and functions as a defense against cold and obesity, but the mechanism for its development is unclear. .. …
The miR-182-5p/FGF21/acetylcholine axis mediates the crosstalk between adipocytes and macrophages to promote beige fat thermogenesis.
Meng W, Xiao T, Liang X, Wen J, Peng X, Wang J, Zou Y, Liu J, Bialowas C, Luo H, Zhang Y, Liu B, Zhang J, Hu F, Liu M, Dong LQ, Zhou Z, Liu F, Bai J. Meng W, et al. JCI Insight. 2021 Sep 8;6(17):e150249. doi: 10.1172/jci.insight.150249. JCI Insight. 2021. PMID: 34264867 Free PMC article.
In this study, we identify adipocyte miRNA-182-5p (miR-182-5p) as a crucial antiobesity molecule that stimulated beige fat thermogenesis by promoting the crosstalk between adipocytes and macrophages. miR-182-5p was highly enriched in thermogenic adipocytes, and its express …
In this study, we identify adipocyte miRNA-182-5p (miR-182-5p) as a crucial antiobesity molecule that stimulated beige fat thermogene …
Adipose tissue in control of metabolism.
Luo L, Liu M. Luo L, et al. J Endocrinol. 2016 Dec;231(3):R77-R99. doi: 10.1530/JOE-16-0211. J Endocrinol. 2016. PMID: 27935822 Free PMC article. Review.
On the other hand, adipose tissue acts as an endocrine organ and produces numerous bioactive factors such as adipokines that communicate with other organs and modulate a range of metabolic pathways. Moreover, brown and beige adipose tissue burn lipid by dissipating energy …
On the other hand, adipose tissue acts as an endocrine organ and produces numerous bioactive factors such as adipokines that communicate wit …
miR-130b/301b Is a Negative Regulator of Beige Adipogenesis and Energy Metabolism In Vitro and In Vivo.
Luo W, Kim Y, Jensen ME, Herlea-Pana O, Wang W, Rudolph MC, Friedman JE, Chernausek SD, Jiang S. Luo W, et al. Diabetes. 2022 Nov 1;71(11):2360-2371. doi: 10.2337/db22-0205. Diabetes. 2022. PMID: 36001751 Free PMC article.
Thermogenic brown or beige adipocytes dissipate energy in the form of heat and thereby counteract obesity and related metabolic complications. The miRNA cluster miR-130b/301b is highly expressed in adipose tissues and has been implicated in metabolic diseases as a posttran …
Thermogenic brown or beige adipocytes dissipate energy in the form of heat and thereby counteract obesity and related metabolic compl …
NNMT is induced dynamically during beige adipogenesis in adipose tissues depot-specific manner.
Jia R, Wei X, Jiang J, Yang Z, Huang J, Liu J, Yan J, Luo X. Jia R, et al. J Physiol Biochem. 2022 Feb;78(1):169-183. doi: 10.1007/s13105-021-00851-8. Epub 2021 Oct 26. J Physiol Biochem. 2022. PMID: 34699038
We determine whether NNMT plays important role in energy metabolism during the beige adipogenesis in vivo and in vitro. Male C57BL/6 mice at 8 weeks old were exposed to 4 for 1, 2, 3, 4, and 5 days, respectively. ...Above all, NNMT was induced in WAT during the 'cold remod …
We determine whether NNMT plays important role in energy metabolism during the beige adipogenesis in vivo and in vitro. Male C57BL/6 …
42 results