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Showing results for bayer tubulin
Search for Bayaer Tubuxin instead (1 results)
An overview on anti-tubulin agents for the treatment of lymphoma patients.
Barreca M, Stathis A, Barraja P, Bertoni F. Barreca M, et al. Pharmacol Ther. 2020 Jul;211:107552. doi: 10.1016/j.pharmthera.2020.107552. Epub 2020 Apr 17. Pharmacol Ther. 2020. PMID: 32305312 Review.
Anti-tubulin agents constitute a large class of compounds with broad activity both in solid tumors and hematologic malignancies, due to the interference with microtubule dynamics. ...Several anti-tubulin agents are indicated in the treatment of patients with lymphom …
Anti-tubulin agents constitute a large class of compounds with broad activity both in solid tumors and hematologic malignancies, due …
Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health.
Strausz S, Ruotsalainen S, Ollila HM, Karjalainen J, Kiiskinen T, Reeve M, Kurki M, Mars N, Havulinna AS, Luonsi E, Mansour Aly D, Ahlqvist E, Teder-Laving M, Palta P, Groop L, Mägi R, Mäkitie A, Salomaa V, Bachour A, Tuomi T; FinnGen; Palotie A, Palotie T, Ripatti S. Strausz S, et al. Eur Respir J. 2021 May 6;57(5):2003091. doi: 10.1183/13993003.03091-2020. Print 2021 May. Eur Respir J. 2021. PMID: 33243845 Free article.
In a BMI-adjusted analysis, an association was observed for rs10507084 near RMST/NEDD1 (rhabdomyosarcoma 2 associated transcript/NEDD1 gamma-tubulin ring complex targeting factor). We found high genetic correlations between OSA and BMI (r(g)=0.72 (95% CI 0.62-0.83)), and w …
In a BMI-adjusted analysis, an association was observed for rs10507084 near RMST/NEDD1 (rhabdomyosarcoma 2 associated transcript/NEDD1 gamma …
Vasohibin-1 has alpha-tubulin detyrosinating activity in glomerular podocytes.
Mifune T, Tanabe K, Nakashima Y, Tanimura S, Sugiyama H, Sato Y, Wada J. Mifune T, et al. Biochem Biophys Res Commun. 2022 Apr 9;599:93-99. doi: 10.1016/j.bbrc.2022.02.047. Epub 2022 Feb 12. Biochem Biophys Res Commun. 2022. PMID: 35180473 Free article.
Microtubule structure and function can be affected by post-translational modification of tubulin, including detyrosination. Recent studies have shown that vasohibin-1 (VASH1), an antiangiogenic factor, has tubulin carboxypeptidase activity that causes detyrosination …
Microtubule structure and function can be affected by post-translational modification of tubulin, including detyrosination. Recent st …
Resistance to anti-tubulin agents: From vinca alkaloids to epothilones.
Krause W. Krause W. Cancer Drug Resist. 2019 Mar 19;2(1):82-106. doi: 10.20517/cdr.2019.06. eCollection 2019. Cancer Drug Resist. 2019. PMID: 35582143 Free PMC article. Review.
Resistance is a major problem in vinca and taxane chemotherapy and arises in most cases from overexpression of efflux pumps that transport the drugs out of the cancer cells and from modifications of the target, the microtubules, by overexpression of tubulin isotypes or by …
Resistance is a major problem in vinca and taxane chemotherapy and arises in most cases from overexpression of efflux pumps that transport t …
A tripartite mode of action approach for investigating the impact of aneugens on tubulin polymerization.
Stock V, Sutter A, Raschke M, Queisser N. Stock V, et al. Environ Mol Mutagen. 2018 Apr;59(3):188-201. doi: 10.1002/em.22158. Epub 2017 Dec 4. Environ Mol Mutagen. 2018. PMID: 29205516
We here report a tripartite mode of action approach comprising a cell-free biochemical polymerization assay and the cell-based methods cellular imaging and flow cytometry. The biochemical assay measures tubulin polymerization over time whereas the two cell-based assays qua …
We here report a tripartite mode of action approach comprising a cell-free biochemical polymerization assay and the cell-based methods cellu …
Safety and activity of anti-mesothelin antibody-drug conjugate anetumab ravtansine in combination with pegylated-liposomal doxorubicin in platinum-resistant ovarian cancer: multicenter, phase Ib dose escalation and expansion study.
Santin AD, Vergote I, González-Martín A, Moore K, Oaknin A, Romero I, Diab S, Copeland LJ, Monk BJ, Coleman RL, Herzog TJ, Siegel J, Kasten L, Schlicker A, Schulz A, Köchert K, Walter AO, Childs BH, Elbi C, Bulat I. Santin AD, et al. Int J Gynecol Cancer. 2023 Apr 3;33(4):562-570. doi: 10.1136/ijgc-2022-003927. Int J Gynecol Cancer. 2023. PMID: 36564099 Free PMC article. Clinical Trial.
OBJECTIVES: Anetumab ravtansine is an antibody-drug conjugate consisting of a fully human anti-mesothelin monoclonal antibody conjugated to cytotoxic maytansinoid tubulin inhibitor DM4. Mesothelin is highly expressed in ovarian cancer. ...
OBJECTIVES: Anetumab ravtansine is an antibody-drug conjugate consisting of a fully human anti-mesothelin monoclonal antibody conjugated to …
From seaside to bedside: Current evidence and future perspectives in the treatment of breast cancer using marine compounds.
De Sanctis R, Jacobs F, Benvenuti C, Gaudio M, Franceschini R, Tancredi R, Pedrazzoli P, Santoro A, Zambelli A. De Sanctis R, et al. Front Pharmacol. 2022 Sep 8;13:909566. doi: 10.3389/fphar.2022.909566. eCollection 2022. Front Pharmacol. 2022. PMID: 36160422 Free PMC article. Review.
The main marine-derived drugs that have been studied for the treatment of BC are tubulin-binding agents (eribulin and plocabulin), DNA-targeting agents (cytarabine and minor groove binders-trabectedin and lurbinectedin) and Antibody-Drug Conjugates (ADCs). ...
The main marine-derived drugs that have been studied for the treatment of BC are tubulin-binding agents (eribulin and plocabulin), DN …
Sequential use of novel therapeutics in advanced prostate cancer following docetaxel chemotherapy.
Omlin A, Pezaro C, Gillessen Sommer S. Omlin A, et al. Ther Adv Urol. 2014 Feb;6(1):3-14. doi: 10.1177/1756287213509677. Ther Adv Urol. 2014. PMID: 24489604 Free PMC article. Review.
In the last three years, five novel treatments have been shown to improve survival in metastatic castration-resistant prostate cancer (CRPC). These novel treatments have distinct mechanisms of action: tubulin-binding chemotherapy (cabazitaxel); immunotherapy (sipuleucel-T) …
In the last three years, five novel treatments have been shown to improve survival in metastatic castration-resistant prostate cancer (CRPC) …
Identification of pyrrolo[3',4':3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas.
Barreca M, Spanò V, Rocca R, Bivacqua R, Gualtieri G, Raimondi MV, Gaudio E, Bortolozzi R, Manfreda L, Bai R, Montalbano A, Alcaro S, Hamel E, Bertoni F, Viola G, Barraja P. Barreca M, et al. Eur J Med Chem. 2023 Jun 5;254:115372. doi: 10.1016/j.ejmech.2023.115372. Epub 2023 Apr 12. Eur J Med Chem. 2023. PMID: 37068384
The VL51 cell line was the most sensitive, with an IC(50) value of 0.10 muM for 3z. Our earlier studies had shown that tubulin was a prominent target of many of our oxazole derivatives. We therefore examined their effects on tubulin assembly and colchicine binding. …
The VL51 cell line was the most sensitive, with an IC(50) value of 0.10 muM for 3z. Our earlier studies had shown that tubulin was a …
High-content live-cell multiplex screen for chemogenomic compound annotation based on nuclear morphology.
Tjaden A, Giessmann RT, Knapp S, Schröder M, Müller S. Tjaden A, et al. STAR Protoc. 2022 Oct 26;3(4):101791. doi: 10.1016/j.xpro.2022.101791. eCollection 2022 Dec 16. STAR Protoc. 2022. PMID: 36317177 Free PMC article.
Here, we describe a high-content multiplex screen to investigate cell viability over 48 h, which can be combined with investigating phenotypic features, such as tubulin binding and mitochondrial content, as initial cellular quality control of diverse compounds. ...
Here, we describe a high-content multiplex screen to investigate cell viability over 48 h, which can be combined with investigating phenotyp …
45 results