A microwave-assisted and heteropolyacids-catalysed cyclocondensation reaction for the synthesis of 4(3H)-quinazolinones

Karima Ighilahriz; Baya Boutemeur; Fariza Chami; Cherifa Rabia; Maâmar Hamdi; Safouane M Hamdi

doi:10.3390/molecules13040779

A microwave-assisted and heteropolyacids-catalysed cyclocondensation reaction for the synthesis of 4(3H)-quinazolinones

Molecules. 2008 Apr 3;13(4):779-789. doi: 10.3390/molecules13040779.

Authors

Karima Ighilahriz¹, Baya Boutemeur¹, Fariza Chami², Cherifa Rabia², Maâmar Hamdi¹, Safouane M Hamdi³

Affiliations

¹ Laboratoire de Chimie Organique Appliquée (Equipe Hétérocycles Associée CRAPC). Faculté de Chimie. Université des Sciences et de la Technologie Houari Boumediène. BP 32, El-Alia. 16111 Bab-Ezzouar. Alger, Algeria.
² Laboratoire de Chimie du Gaz Naturel. Faculté de Chimie. Université des Sciences et de la Technologie Houari Boumediène. BP 32, El-Alia. 16111 Bab-Ezzouar. Alger, Algeria.
³ Laboratoire de Biochimie-Purpan, Institut Fédératif de Biologie, CHU Toulouse 330, Avenue de Grande-Bretagne - F- 31059 Toulouse cedex 9, France.

Abstract

We have investigated a microwave-assisted synthesis of 4(3H)-quinazolinones by condensation of anthranilic acid, orthoesters (or formic acid) and substituted anilines,using Keggin-type heteropolyacids (H(3)PW(12)O(40).13H(2)O, H(4)SiW(12)O(40).13H(2)O,H(4)SiMo(12)O(40).13H(2)O or H(3)PMo(12)O(40).13H(2)O) as catalysts. We found that the the use of H(3)PW(12)O(40).13H(2)O acid coupled to microwave irradiation allows a solvent-free, rapid (approximately 13min) and high-yielding reaction.

MeSH terms

Acids / chemistry*
Aniline Compounds / chemistry
Catalysis
Microwaves*
Quinazolinones / chemical synthesis*
Quinazolinones / chemistry
Solvents / chemistry
ortho-Aminobenzoates / chemistry

Substances

Acids
Aniline Compounds
Quinazolinones
Solvents
ortho-Aminobenzoates
anthranilic acid
aniline