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DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing.
Engelberts PJ, Hiemstra IH, de Jong B, Schuurhuis DH, Meesters J, Beltran Hernandez I, Oostindie SC, Neijssen J, van den Brink EN, Horbach GJ, Verploegen S, Labrijn AF, Salcedo T, Schuurman J, Parren PWHI, Breij ECW. Engelberts PJ, et al. Among authors: de jong b. EBioMedicine. 2020 Feb;52:102625. doi: 10.1016/j.ebiom.2019.102625. Epub 2020 Jan 23. EBioMedicine. 2020. PMID: 31981978 Free PMC article.
A human kidney and liver organoid-based multi-organ-on-a-chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell-derived extracellular vesicles.
Nguyen VVT, Ye S, Gkouzioti V, van Wolferen ME, Yengej FY, Melkert D, Siti S, de Jong B, Besseling PJ, Spee B, van der Laan LJW, Horland R, Verhaar MC, van Balkom BWM. Nguyen VVT, et al. Among authors: de jong b. J Extracell Vesicles. 2022 Nov;11(11):e12280. doi: 10.1002/jev2.12280. J Extracell Vesicles. 2022. PMID: 36382606 Free PMC article.
Logic-gated antibody pairs that selectively act on cells co-expressing two antigens.
Oostindie SC, Rinaldi DA, Zom GG, Wester MJ, Paulet D, Al-Tamimi K, van der Meijden E, Scheick JR, Wilpshaar T, de Jong B, Hoff-van den Broek M, Grattan RM, Oosterhoff JJ, Vignau J, Verploegen S, Boross P, Beurskens FJ, Lidke DS, Schuurman J, de Jong RN. Oostindie SC, et al. Among authors: de jong b. Nat Biotechnol. 2022 Oct;40(10):1509-1519. doi: 10.1038/s41587-022-01384-1. Epub 2022 Jul 25. Nat Biotechnol. 2022. PMID: 35879362 Free PMC article.
Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism.
Overdijk MB, Strumane K, Beurskens FJ, Ortiz Buijsse A, Vermot-Desroches C, Vuillermoz BS, Kroes T, de Jong B, Hoevenaars N, Hibbert RG, Lingnau A, Forssmann U, Schuurman J, Parren PWHI, de Jong RN, Breij ECW. Overdijk MB, et al. Among authors: de jong b. Mol Cancer Ther. 2020 Oct;19(10):2126-2138. doi: 10.1158/1535-7163.MCT-20-0044. Epub 2020 Aug 26. Mol Cancer Ther. 2020. PMID: 32847982
12 results