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Molecular epidemiology of virulent E. coli among rural small scale dairy herds and shops: Efficacy of selected marine algal extracts and disinfectants.
Ahmed AS, Diab HM, Alkahtani MA, Alshehri MA, Saber H, Badr H, Dandrawy MK, El-Mansi AA, Shati AA, Ahmed AE. Ahmed AS, et al. Int J Environ Health Res. 2022 Jan;32(1):72-94. doi: 10.1080/09603123.2020.1727422. Epub 2020 Feb 13. Int J Environ Health Res. 2022. PMID: 32053006
Virulent pathotypes of E. coli seriously affect the livestock regarding the misuse of antibiotics. All 180 samples collected from cow's environment and dairy shops in Qena, Egypt were serologically and molecularly positive for coliforms. ...
Virulent pathotypes of E. coli seriously affect the livestock regarding the misuse of antibiotics. All 180 samples collected from cow's …
SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX.
Eldehna WM, Abo-Ashour MF, Berrino E, Vullo D, Ghabbour HA, Al-Rashood ST, Hassan GS, Alkahtani HM, Almehizia AA, Alharbi A, Abdel-Aziz HA, Supuran CT. Eldehna WM, et al. Bioorg Chem. 2019 Mar;83:549-558. doi: 10.1016/j.bioorg.2018.11.014. Epub 2018 Nov 14. Bioorg Chem. 2019. PMID: 30471577
The target tumor-associated isoform hCA IX was undeniably the most affected one (K(I)s: 0.21-7.1 nM), with 6- to 21-fold enhanced activity than SLC-0111 (K(I) = 45 nM). ...
The target tumor-associated isoform hCA IX was undeniably the most affected one (K(I)s: 0.21-7.1 nM), with 6- to 21-fold enhanced act …
Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer.
Eldehna WM, Nocentini A, Al-Rashood ST, Hassan GS, Alkahtani HM, Almehizia AA, Reda AM, Abdel-Aziz HA, Supuran CT. Eldehna WM, et al. Bioorg Chem. 2018 Dec;81:425-432. doi: 10.1016/j.bioorg.2018.09.007. Epub 2018 Sep 7. Bioorg Chem. 2018. PMID: 30219719
All the investigated sulfonamides displayed single- or double-digit nanomolar inhibitory activities towards both hCA IX (K(I)s: 6.2-64.8 nM) and XII (K(I)s: 7.1-55.6 nM) isoforms. All sulfonamides (3a-f, 6a-f and 9a-f) were in vitro examined for their potential anti …
All the investigated sulfonamides displayed single- or double-digit nanomolar inhibitory activities towards both hCA IX (K(I)s: 6.2-6 …
Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity.
Eldehna WM, Abdelrahman MA, Nocentini A, Bua S, Al-Rashood ST, Hassan GS, Bonardi A, Almehizia AA, Alkahtani HM, Alharbi A, Gratteri P, Supuran CT. Eldehna WM, et al. Bioorg Chem. 2019 Sep;90:103102. doi: 10.1016/j.bioorg.2019.103102. Epub 2019 Jul 2. Bioorg Chem. 2019. PMID: 31299596
All the tested hCA isoforms were inhibited by the prepared imidazolones 7a-f in variable degrees with the following K(I)s ranges: 673.2-8169 nM for hCA I, 61.2-592.1 nM for hCA II, 23-155.4 nM for hCA XI, and 21.8-179.6 nM for hCA XII. ...
All the tested hCA isoforms were inhibited by the prepared imidazolones 7a-f in variable degrees with the following K(I)s ranges: 673 …
Novel Diamide-Based Benzenesulfonamides as Selective Carbonic Anhydrase IX Inhibitors Endowed with Antitumor Activity: Synthesis, Biological Evaluation and In Silico Insights.
Abdelrahman MA, Eldehna WM, Nocentini A, Bua S, Al-Rashood ST, Hassan GS, Bonardi A, Almehizia AA, Alkahtani HM, Alharbi A, Gratteri P, Supuran CT. Abdelrahman MA, et al. Int J Mol Sci. 2019 May 20;20(10):2484. doi: 10.3390/ijms20102484. Int J Mol Sci. 2019. PMID: 31137489 Free PMC article.
The target tumor-associated isoforms hCA IX and XII were undeniably the most affected ones (K(I)s: 8.3-123.3 and 9.8-134.5 nM, respectively). Notably, diamides 5a and 5h stood out as a single-digit nanomolar hCA IX inhibitors (K(I)s = 8.8 and 8.3 nM). ...
The target tumor-associated isoforms hCA IX and XII were undeniably the most affected ones (K(I)s: 8.3-123.3 and 9.8-134.5 nM, respec …