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Ofatumumab versus Teriflunomide in Multiple Sclerosis.
Hauser SL, Bar-Or A, Cohen JA, Comi G, Correale J, Coyle PK, Cross AH, de Seze J, Leppert D, Montalban X, Selmaj K, Wiendl H, Kerloeguen C, Willi R, Li B, Kakarieka A, Tomic D, Goodyear A, Pingili R, Häring DA, Ramanathan K, Merschhemke M, Kappos L; ASCLEPIOS I and ASCLEPIOS II Trial Groups. Hauser SL, et al. N Engl J Med. 2020 Aug 6;383(6):546-557. doi: 10.1056/NEJMoa1917246. N Engl J Med. 2020. PMID: 32757523 Clinical Trial.
CONCLUSIONS: Among patients with multiple sclerosis, ofatumumab was associated with lower annualized relapse rates than teriflunomide. (Funded by Novartis; ASCLEPIOS I and II ClinicalTrials.gov numbers, NCT02792218 and NCT02792231.)....
CONCLUSIONS: Among patients with multiple sclerosis, ofatumumab was associated with lower annualized relapse rates than teriflunomide. (Fund …
Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children.
Peariso K, Arya R, Glauser T, Abend NS, Barcia Aguilar C, Amengual-Gual M, Anderson A, Appavu BL, Brenton JN, Carpenter J, Chapman KE, Clark J, Gaillard WD, Gaínza-Lein M, Goldstein J, Goodkin H, Grinspan Z, Guerriero RM, Horn PS, Huh L, Kahoud R, Kelley SA, Kossoff EH, Kapur K, Lai YC, Marquis BO, McDonough T, Mikati MA, Morgan L, Novotny E, Ostendorf AP, Payne ET, Piantino J, Riviello J, Sands T, Stafstrom CE, Tasker RC, Tchapyjnikov D, Vasquez A, Wainwright MS, Wilfong A, Williams K, Loddenkemper T; for Pediatric Status Epilepticus Research Group (pSERG). Peariso K, et al. Neurology. 2023 Aug 1;101(5):e546-e557. doi: 10.1212/WNL.0000000000207472. Epub 2023 Jun 9. Neurology. 2023. PMID: 37295955
Early attainment of these variables may help care for pediatric rESE in a more patient-tailored manner. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that patient and clinical factors may predict RSE in children with convulsive seizures....
Early attainment of these variables may help care for pediatric rESE in a more patient-tailored manner. CLASSIFICATION OF EVIDENCE: This stu …
Rat Ace allele variation determines susceptibility to AngII-induced renal damage.
Kamilic J, Hamming I, Lely AT, Korstanje R, Schulze U, Poppinga WJ, Turner AJ, Clarke NE, van Goor H, Navis GJ. Kamilic J, et al. J Renin Angiotensin Aldosterone Syst. 2011 Dec;12(4):420-9. doi: 10.1177/1470320311415886. Epub 2011 Jul 25. J Renin Angiotensin Aldosterone Syst. 2011. PMID: 21788250 Free PMC article.
INTRODUCTION: Ace b/l polymorphism in rats is associated with differential tissue angiotensin-converting enzyme (ACE) expression and activity, and susceptibility to renal damage. ...METHODS: We investigated the reaction of these alleles on chronic angiotensin II
INTRODUCTION: Ace b/l polymorphism in rats is associated with differential tissue angiotensin-converting enzyme (ACE) expressi …
DM, but not cathepsin L, is required to control an aerosol infection with Mycobacterium tuberculosis.
Nepal RM, Vesosky B, Turner J, Bryant P. Nepal RM, et al. J Leukoc Biol. 2008 Oct;84(4):1011-8. doi: 10.1189/jlb.1207852. Epub 2008 Jun 30. J Leukoc Biol. 2008. PMID: 18591414
Herein, we examined the requirement for each of these components in mice to control a low-dose aerosol infection with Mycobacterium tuberculosis (MTB). Mice lacking Cat B, -L, or -S were similar to wild-type in their ability to control the growth and dissemination o …
Herein, we examined the requirement for each of these components in mice to control a low-dose aerosol infection with Mycobacterium tubercul …
Emergent Carotid Stenting Plus Thrombectomy After Thrombolysis in Tandem Strokes: Analysis of the TITAN Registry.
Anadani M, Spiotta AM, Alawieh A, Turjman F, Piotin M, Haussen DC, Nogueira RG, Papanagiotou P, Siddiqui AH, Lapergue B, Dorn F, Cognard C, Ribo M, Psychogios MN, Labeyrie MA, Mazighi M, Biondi A, Anxionnat R, Bracard S, Richard S, Gory B; TITAN (Thrombectomy In TANdem Lesions) Investigators. Anadani M, et al. Stroke. 2019 Aug;50(8):2250–2252. doi: 10.1161/STROKEAHA.118.024733. Epub 2019 Jun 17. Stroke. 2019. PMID: 31577899
Intracerebral hemorrhages were classified according to the European Cooperative Acute Stroke Study II criteria. RESULTS: Among 205 patients included in the present study, 125 (60%) received prior IVT. ...
Intracerebral hemorrhages were classified according to the European Cooperative Acute Stroke Study II criteria. RESULTS: Among 205 pa …