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Brucellosis in humans--etiology, diagnostics, clinical forms.
Galińska EM, Zagórski J. Galińska EM, et al. Ann Agric Environ Med. 2013;20(2):233-8. Ann Agric Environ Med. 2013. PMID: 23772567 Free article. Review.
The etiologic factors of brucellosis are small, aerobic Gram-negative rods of the genus Brucella, which currently contains ten species: B. abortus, B. suis, B. ovis, B. melitensis, B. canis, B. neotomae, B. pinnipedialis, B. …
The etiologic factors of brucellosis are small, aerobic Gram-negative rods of the genus Brucella, which currently contains ten species: B …
Modular nanoarray vaccine for SARS-CoV-2.
Zagorski K, Pandey K, Rajaiah R, Olwenyi OA, Bade AN, Acharya A, Johnston M, Filliaux S, Lyubchenko YL, Byrareddy SN. Zagorski K, et al. Nanomedicine. 2022 Nov;46:102604. doi: 10.1016/j.nano.2022.102604. Epub 2022 Sep 13. Nanomedicine. 2022. PMID: 36113829 Free PMC article.
The vaccine is based on the rational design of an immunogen containing two defined B-cell epitopes from the spike glycoprotein of SARS-CoV-2 and the universal T-helper epitope PADRE. ...
The vaccine is based on the rational design of an immunogen containing two defined B-cell epitopes from the spike glycoprotein of SAR …
Immunogenicity of MultiTEP-Platform-Based Recombinant Protein Vaccine, PV-1950R, Targeting Three B-Cell Antigenic Determinants of Pathological alpha-Synuclein.
Zagorski K, Chailyan G, Hovakimyan A, Antonyan T, Kiani Shabestari S, Petrushina I, Davtyan H, Cribbs DH, Blurton-Jones M, Masliah E, Agadjanyan MG, Ghochikyan A. Zagorski K, et al. Int J Mol Sci. 2022 May 29;23(11):6080. doi: 10.3390/ijms23116080. Int J Mol Sci. 2022. PMID: 35682759 Free PMC article.
The most immunogenic and preclinically effective vaccine, PV-1950D, targeting three B-cell epitopes of pathological alpha-Syn simultaneously, has been selected for future IND-enabling studies. ...
The most immunogenic and preclinically effective vaccine, PV-1950D, targeting three B-cell epitopes of pathological alpha-Syn simulta …
Immunogenicity of MultiTEP platform technology-based Tau vaccine in non-human primates.
Hovakimyan A, Zagorski K, Chailyan G, Antonyan T, Melikyan L, Petrushina I, Batt DG, King O, Ghazaryan M, Donthi A, Foose C, Petrovsky N, Cribbs DH, Agadjanyan MG, Ghochikyan A. Hovakimyan A, et al. NPJ Vaccines. 2022 Oct 12;7(1):117. doi: 10.1038/s41541-022-00544-3. NPJ Vaccines. 2022. PMID: 36224191 Free PMC article.
We have demonstrated that AV-1980R/A is highly immunogenic in these NHPs, activating a broad but unique to each monkey repertoire of MultiTEP-specific T helper (Th) cells that, in turn, activate B cells specific to PAD. The resulting anti-PAD IgG antibodies recognize patho …
We have demonstrated that AV-1980R/A is highly immunogenic in these NHPs, activating a broad but unique to each monkey repertoire of MultiTE …
Characterization and preclinical evaluation of the cGMP grade DNA based vaccine, AV-1959D to enter the first-in-human clinical trials.
Petrushina I, Hovakimyan A, Harahap-Carrillo IS, Davtyan H, Antonyan T, Chailyan G, Kazarian K, Antonenko M, Jullienne A, Hamer MM, Obenaus A, King O, Zagorski K, Blurton-Jones M, Cribbs DH, Lander H, Ghochikyan A, Agadjanyan MG. Petrushina I, et al. Neurobiol Dis. 2020 Jun;139:104823. doi: 10.1016/j.nbd.2020.104823. Epub 2020 Feb 28. Neurobiol Dis. 2020. PMID: 32119976 Free PMC article. Review.
Multiple immunizations of Tg-SwDI mice with AV-1959D did not induce T and B cell infiltration, glial activation, vascular deposition of Abeta, or neuronal degeneration (necrosis and apoptosis) greater than that in the control group determined by immunohistochemistry of bra …
Multiple immunizations of Tg-SwDI mice with AV-1959D did not induce T and B cell infiltration, glial activation, vascular deposition …
Peptide Nanoarray Scaffold Vaccine for SARS-COV-2 and Its Variants of Concerns.
Zagorski K, Pandey K, Rajaiah R, Olwenyi O, Bade A, Acharya A, Johnston M, Filliaux S, Lyubchenko Y, Byrareddy S. Zagorski K, et al. Res Sq [Preprint]. 2022 Jan 24:rs.3.rs-1206402. doi: 10.21203/rs.3.rs-1206402/v1. Res Sq. 2022. PMID: 35118461 Free PMC article. Preprint.
The vaccine is based on the rational design of an immunogen containing two defined B-cell epitopes from the spike protein of SARS-Co-V2 and a universal T-helper epitope PADRE assembled on the DNA scaffold. ...
The vaccine is based on the rational design of an immunogen containing two defined B-cell epitopes from the spike protein of SARS-Co- …
MultiTEP platform-based DNA vaccines for alpha-synucleinopathies: preclinical evaluation of immunogenicity and therapeutic potency.
Davtyan H, Zagorski K, Petrushina I, Kazarian K, Goldberg NRS, Petrosyan J, Blurton-Jones M, Masliah E, Cribbs DH, Agadjanyan MG, Ghochikyan A. Davtyan H, et al. Neurobiol Aging. 2017 Nov;59:156-170. doi: 10.1016/j.neurobiolaging.2017.08.006. Epub 2017 Aug 10. Neurobiol Aging. 2017. PMID: 28870518 Free PMC article.
Taking advantage of the universality of MultiTEP platform, we developed DNA vaccines targeting 3 B-cell epitopes (amino acids [aa]85-99, aa109-126, and aa126-140) of human alpha-synuclein (halpha-Syn) separately or all 3 epitopes simultaneously. ...Based on these results, …
Taking advantage of the universality of MultiTEP platform, we developed DNA vaccines targeting 3 B-cell epitopes (amino acids [aa]85- …
Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies.
Kim C, Hovakimyan A, Zagorski K, Antonyan T, Petrushina I, Davtyan H, Chailyan G, Hasselmann J, Iba M, Adame A, Rockenstein E, Szabo M, Blurton-Jones M, Cribbs DH, Ghochikyan A, Masliah E, Agadjanyan MG. Kim C, et al. NPJ Vaccines. 2022 Jan 10;7(1):1. doi: 10.1038/s41541-021-00424-2. NPJ Vaccines. 2022. PMID: 35013319 Free PMC article.
Here, we are reporting on the efficacy and immunogenicity of these vaccines targeting three B-cell epitopes of halpha-Syn aa85-99 (PV-1947D), aa109-126 (PV-1948D), aa126-140 (PV-1949D) separately or simultaneously (PV-1950D) in a mouse model of synucleinopathies mimicking …
Here, we are reporting on the efficacy and immunogenicity of these vaccines targeting three B-cell epitopes of halpha-Syn aa85-99 (PV …
Liver transplantation outcomes among Caucasians, Asian Americans, and African Americans with hepatitis B.
Bzowej N, Han S, Degertekin B, Keeffe EB, Emre S, Brown R, Reddy R, Lok AS; National Institutes of Health Hepatitis B Virus Orthotopic Liver Transplantation Study Group. Bzowej N, et al. Liver Transpl. 2009 Sep;15(9):1010-20. doi: 10.1002/lt.21759. Liver Transpl. 2009. PMID: 19718627 Free PMC article.
Several previous studies found that Asians transplanted for hepatitis B virus (HBV) infection had worse post-transplant outcomes than Caucasians. ...In conclusion, we found similar waitlist and post-transplant outcomes among Caucasians, Asian Americans, and African America …
Several previous studies found that Asians transplanted for hepatitis B virus (HBV) infection had worse post-transplant outcomes than …
40 results