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TYROBP/DAP12 knockout in Huntington's disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration.
Creus-Muncunill J, Haure-Mirande JV, Mattei D, Bons J, Ramirez AV, Hamilton BW, Corwin C, Chowdhury S, Schilling B, Ellerby LM, Ehrlich ME. Creus-Muncunill J, et al. Among authors: hamilton bw. J Neuroinflammation. 2024 Mar 8;21(1):66. doi: 10.1186/s12974-024-03052-4. J Neuroinflammation. 2024. PMID: 38459557 Free PMC article.
Postnatal Conditional Deletion of Bcl11b in Striatal Projection Neurons Mimics the Transcriptional Signature of Huntington's Disease.
Song S, Creus Muncunill J, Galicia Aguirre C, Tshilenge KT, Hamilton BW, Gerencser AA, Benlhabib H, Cirnaru MD, Leid M, Mooney SD, Ellerby LM, Ehrlich ME. Song S, et al. Among authors: hamilton bw. Biomedicines. 2022 Sep 23;10(10):2377. doi: 10.3390/biomedicines10102377. Biomedicines. 2022. PMID: 36289639 Free PMC article.