A new soluble and bioactive polymorph of praziquantel.
Zanolla D, Perissutti B, Passerini N, Chierotti MR, Hasa D, Voinovich D, Gigli L, Demitri N, Geremia S, Keiser J, Cerreia Vioglio P, Albertini B.
Zanolla D, et al.
Eur J Pharm Biopharm. 2018 Jun;127:19-28. doi: 10.1016/j.ejpb.2018.01.018. Epub 2018 Jan 31.
Eur J Pharm Biopharm. 2018.
PMID: 29409939
Free article.
The preparation of the crystalline polymorph was realized via a neat grinding process in a vibrational mill. The new phase (Form B) was chemically identical to the starting material (as proved by HPLC, (1)H NMR, and polarimetry), but showed different physical properties (a …
The preparation of the crystalline polymorph was realized via a neat grinding process in a vibrational mill. The new phase (Form B) w …