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Amelioration of acrylamide induced neurotoxicity by benzo[b]thiophene analogs via glutathione redox dynamics in zebrafish larvae.
Haridevamuthu B, Manjunathan T, Guru A, Ranjith Wilson Alphonse C, Boopathi S, Murugan R, Gatasheh MK, Atef Hatamleh A, Juliet A, Gopinath P, Arockiaraj J. Haridevamuthu B, et al. Brain Res. 2022 Aug 1;1788:147941. doi: 10.1016/j.brainres.2022.147941. Epub 2022 May 10. Brain Res. 2022. PMID: 35550141
Acrylamide forms adduct in presynaptic neurons leading to neuroinflammation which is also a factor to consider. In this present study, we have explored whether our benzo[b]thiophene analogs, 1-(3-hydroxybenzo[b]thiophen-2-yl) ethanone (BP) and 1-(3-hydroxybenzo[b
Acrylamide forms adduct in presynaptic neurons leading to neuroinflammation which is also a factor to consider. In this present study, we ha …
Hydroxyl containing benzo[b]thiophene analogs mitigates the acrylamide induced oxidative stress in the zebrafish larvae by stabilizing the glutathione redox cycle.
Haridevamuthu B, Manjunathan T, Guru A, Kumar RS, Rajagopal R, Kuppusamy P, Juliet A, Gopinath P, Arockiaraj J. Haridevamuthu B, et al. Life Sci. 2022 Jun 1;298:120507. doi: 10.1016/j.lfs.2022.120507. Epub 2022 Mar 28. Life Sci. 2022. PMID: 35358593
AIMS: This study aims to elucidate a systematic free-radical quenching ability of synthesized benzo[b]thiophene derivatives using in vitro assays and acrylamide induced oxidatively stressed model in zebrafish larvae. ...The antioxidant system in zebrafish larvae was dysreg …
AIMS: This study aims to elucidate a systematic free-radical quenching ability of synthesized benzo[b]thiophene derivatives using in …
Functionalized Sulfur-Containing Heterocyclic Analogs Induce Sub-G1 Arrest and Apoptotic Cell Death of Laryngeal Carcinoma In Vitro.
Haridevamuthu B, Manjunathan T, Wilson Alphonse CR, Kumar RS, Thanigaivel S, Chandra Kishore S, Sundaram V, Gopinath P, Arockiaraj J, Bellucci S. Haridevamuthu B, et al. Molecules. 2023 Feb 15;28(4):1856. doi: 10.3390/molecules28041856. Molecules. 2023. PMID: 36838844 Free PMC article.
In this study, we speculate that the hydroxyl-containing benzo[b]thiophene analogs, 1-(3-hydroxybenzo[b]thiophen-2-yl) ethanone (BP) and 1-(3-hydroxybenzo[b]thiophen-2-yl) propan-1-one hydrate (EP), might possess antiproliferative activity against cancer cell …
In this study, we speculate that the hydroxyl-containing benzo[b]thiophene analogs, 1-(3-hydroxybenzo[b]thiophen-2-yl) ethanon …