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Page 1
Did you mean became dione (128 results)?
Recent developments in the synthesis of the isoquinoline-1,3(2H,4H)-dione by radical cascade reaction.
Niu YN, Xia XF. Niu YN, et al. Org Biomol Chem. 2022 Oct 19;20(40):7861-7885. doi: 10.1039/d2ob01554d. Org Biomol Chem. 2022. PMID: 36185038 Review.
In recent years, isoquinoline-1,3(2H,4H)-dione compounds have attracted extensive attention from synthetic chemists, with the aim of finding simple, mild, green and efficient synthetic methods. In this review, we summarize the diverse range of synthetic methods employing a …
In recent years, isoquinoline-1,3(2H,4H)-dione compounds have attracted extensive attention from synthetic chemists, with the aim of …
DBU/O2-Mediated Oxidation of Dienones.
Athawale PR, Kalmode HP, Reddy DS. Athawale PR, et al. J Org Chem. 2021 Jul 2;86(13):9200-9205. doi: 10.1021/acs.joc.1c00529. Epub 2021 Jun 18. J Org Chem. 2021. PMID: 34142825
Herein, we describe a DBU/O(2)-promoted novel method for oxidation of dienones to 2,6-dione derivatives. The reaction involves treatment of a dienone with DBU in acetonitrile employing molecular oxygen as the oxidant. ...This transformation proceeds through a peroxide inte …
Herein, we describe a DBU/O(2)-promoted novel method for oxidation of dienones to 2,6-dione derivatives. The reaction involves treatm …
Guanidine Derivatives of Quinazoline-2,4(1H,3H)-Dione as NHE-1 Inhibitors and Anti-Inflammatory Agents.
Spasov A, Ozerov A, Kosolapov V, Gurova N, Kucheryavenko A, Naumenko L, Babkov D, Sirotenko V, Taran A, Borisov A, Sokolova E, Klochkov V, Merezhkina D, Miroshnikov M, Ovsyankina N, Smirnov A, Velikorodnaya Y. Spasov A, et al. Life (Basel). 2022 Oct 20;12(10):1647. doi: 10.3390/life12101647. Life (Basel). 2022. PMID: 36295082 Free PMC article.
Previously, we showed NHE-1 inhibitory, anti-inflammatory, antiplatelet, intraocular pressure lowering, and antiglycating activity for a series of quinazoline-2,4(1H,3H)-diones and quinazoline-4(3H)-one guanidine derivatives. In the present work, novel N1,N3-bis-substitute …
Previously, we showed NHE-1 inhibitory, anti-inflammatory, antiplatelet, intraocular pressure lowering, and antiglycating activity for a ser …
Thiazolidine-2,4-diones: progress towards multifarious applications.
Jain VS, Vora DK, Ramaa CS. Jain VS, et al. Bioorg Med Chem. 2013 Apr 1;21(7):1599-620. doi: 10.1016/j.bmc.2013.01.029. Epub 2013 Jan 24. Bioorg Med Chem. 2013. PMID: 23419324 Review.
Varied substituents on the thiazolidine-2,4-dione nucleus have provided a wide spectrum of biological activities. ...This discussion will further help in the development of novel thiazolidine-2,4-dione compounds....
Varied substituents on the thiazolidine-2,4-dione nucleus have provided a wide spectrum of biological activities. ...This discussion …
Application of cyclohexane-1,3-diones for six-membered oxygen-containing heterocycles synthesis.
Sharma D, Kumar M, Das P. Sharma D, et al. Bioorg Chem. 2021 Feb;107:104559. doi: 10.1016/j.bioorg.2020.104559. Epub 2020 Dec 15. Bioorg Chem. 2021. PMID: 33418315 Review.
Cyclohexan-1,3-dione derivatives are versatile scaffolds for the synthesis of a variety of value-added organic molecules including heterocycles and natural products. ...The studies reported in this review article involved the synthesis of six-membered oxygen-containing het …
Cyclohexan-1,3-dione derivatives are versatile scaffolds for the synthesis of a variety of value-added organic molecules including he …
Novel Strategy for Non-Aqueous Bioconjugation of Substituted Phenyl-1,2,4-triazole-3,5-dione Analogues.
Hiscocks HG, Ung AT, Pascali G. Hiscocks HG, et al. Molecules. 2022 Oct 7;27(19):6667. doi: 10.3390/molecules27196667. Molecules. 2022. PMID: 36235204 Free PMC article.
A novel 4-[4-(pentafluoro-lambda6-sulfanyl)phenyl]-1,2,4-triazole-3,5-dione (5a) was synthesised as a potential [(18)F]radio-prosthetic group for radiolabelling peptides and proteins via selective bioconjugation with the phenolic side chains of tyrosine residues. ...
A novel 4-[4-(pentafluoro-lambda6-sulfanyl)phenyl]-1,2,4-triazole-3,5-dione (5a) was synthesised as a potential [(18)F]radio-prosthet …
Synthesis, cytotoxicity, and antibacterial studies of 2,4,5,6-substituted hexahydro-1H-isoindole-1,3(2H)-dione.
Yetişkin E, Gündoğdu Ö, Mete D, Çelebioğlu N, Kara Y, Şanlı-Mohamed G. Yetişkin E, et al. Chem Biol Drug Des. 2023 Dec;102(6):1448-1457. doi: 10.1111/cbdd.14335. Epub 2023 Sep 15. Chem Biol Drug Des. 2023. PMID: 37712451
In this study, synthesis of novel isoindole-1,3-dione analogues bearig halo, hydroxy, and acetoxy groups at the position 4,5,6 of the bicyclic imide ring was performed to examine their potential anticancer effects against some cell lines. ...The C-2 selective ring-opening …
In this study, synthesis of novel isoindole-1,3-dione analogues bearig halo, hydroxy, and acetoxy groups at the position 4,5,6 of the …
Chemical Synthesis, Mechanism of Action and Anticancer Potential of Medicinally Important Thiazolidin-2,4-dione Derivatives: A Review.
Kumar H, Deep A, Marwaha RK. Kumar H, et al. Mini Rev Med Chem. 2019;19(18):1474-1516. doi: 10.2174/1389557519666190513093618. Mini Rev Med Chem. 2019. PMID: 31092179 Review.
Thiazolidin-2,4-dione (TZD) possessing an active methylene constitute an important chemical class of compounds for the development of new drugs. ...In the present review, the synthesis of various derivatives of thiazolidine-2,4-diones, their mechanism of action and …
Thiazolidin-2,4-dione (TZD) possessing an active methylene constitute an important chemical class of compounds for the development of …
Access and Modulation of Substituted Pyrrolo[3,4-c]pyrazole-4,6-(2H,5H)-diones.
Ejjoummany A, Elie J, El Hakmaoui A, Akssira M, Routier S, Buron F. Ejjoummany A, et al. Molecules. 2023 Aug 1;28(15):5811. doi: 10.3390/molecules28155811. Molecules. 2023. PMID: 37570778 Free PMC article.
The first access to polyfunctionnalized pyrrolo[3,4-c]pyrazole-4,6-(2H,5H)-dione derivatives is reported. The series were generated from diethyl acetylenedicarboxylate and arylhydrazines, which afforded the key intermediates bearing two functional positions. ...Moreover, a …
The first access to polyfunctionnalized pyrrolo[3,4-c]pyrazole-4,6-(2H,5H)-dione derivatives is reported. The series were generated f …
Synthesis of 2a,8b-Dihydrocyclobuta[a]naphthalene-3,4-diones.
Schmidt K, Margaretha P. Schmidt K, et al. Beilstein J Org Chem. 2010 Jul 13;6:76. doi: 10.3762/bjoc.6.76. Beilstein J Org Chem. 2010. PMID: 20703383 Free PMC article.
On irradiation (lambda = 350 nm) in neat hex-1-yne, naphthalene-1,2-dione monoacetals 1 afford mixtures of pentacyclic photodimers and up to 25% (isolated yield) of mixed photocycloadducts 2. ...
On irradiation (lambda = 350 nm) in neat hex-1-yne, naphthalene-1,2-dione monoacetals 1 afford mixtures of pentacyclic photodimers an …
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