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Synthesis of 5α-androstane-17-spiro-δ-lactones with a 3-keto, 3-hydroxy, 3-spirocarbamate or 3-spiromorpholinone as inhibitors of 17β-hydroxysteroid dehydrogenases.
Molecules. 2013 Jan 11;18(1):914-33. doi: 10.3390/molecules18010914.
Molecules. 2013.
PMID: 23344201
Free PMC article.
Androsterone 3alpha-ether-3beta-substituted and androsterone 3beta-substituted derivatives as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: chemical synthesis and structure-activity relationship.
Tchédam Ngatcha B, Luu-The V, Labrie F, Poirier D.
Tchédam Ngatcha B, et al.
J Med Chem. 2005 Aug 11;48(16):5257-68. doi: 10.1021/jm058179h.
J Med Chem. 2005.
PMID: 16078844
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Androsterone derivatives substituted at position 16: chemical synthesis, inhibition of type 3 17beta-hydroxysteroid dehydrogenase, binding affinity for steroid receptors and proliferative/antiproliferative activity on Shionogi (AR+) cells.
Tchédam-Ngatcha B, Luu-The V, Poirier D.
Tchédam-Ngatcha B, et al.
J Enzyme Inhib Med Chem. 2002 Jun;17(3):155-65. doi: 10.1080/1475636021000002067.
J Enzyme Inhib Med Chem. 2002.
PMID: 12443041
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3Beta-alkyl-androsterones as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: inhibitory potency in intact cells, selectivity towards isoforms 1, 2, 5 and 7, binding affinity for steroid receptors, and proliferative/antiproliferative activities on AR+ and ER+ cell lines.
Ngatcha BT, Laplante Y, Labrie F, Luu-The V, Poirier D.
Ngatcha BT, et al.
Mol Cell Endocrinol. 2006 Mar 27;248(1-2):225-32. doi: 10.1016/j.mce.2005.10.023. Epub 2005 Dec 15.
Mol Cell Endocrinol. 2006.
PMID: 16359782
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