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Genetic deletion of p66shc and/or cyclophilin D results in decreased pulmonary vascular tone.
Gierhardt M, Pak O, Sydykov A, Kraut S, Schäffer J, Garcia C, Veith C, Zeidan EM, Brosien M, Quanz K, Esfandiary A, Saraji A, Hadzic S, Kojonazarov B, Wilhelm J, Ghofrani HA, Schermuly RT, Seeger W, Grimminger F, Herden C, Schulz R, Weissmann N, Heger J, Sommer N. Gierhardt M, et al. Among authors: esfandiary a. Cardiovasc Res. 2022 Jan 7;118(1):305-315. doi: 10.1093/cvr/cvaa310. Cardiovasc Res. 2022. PMID: 33119054 Free PMC article.
Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension.
Pak O, Scheibe S, Esfandiary A, Gierhardt M, Sydykov A, Logan A, Fysikopoulos A, Veit F, Hecker M, Kroschel F, Quanz K, Erb A, Schäfer K, Fassbinder M, Alebrahimdehkordi N, Ghofrani HA, Schermuly RT, Brandes RP, Seeger W, Murphy MP, Weissmann N, Sommer N. Pak O, et al. Among authors: esfandiary a. Eur Respir J. 2018 Feb 1:1701024. doi: 10.1183/13993003.01024-2017. Online ahead of print. Eur Respir J. 2018. PMID: 29419444
Protection against pressure overload-induced right heart failure by uncoupling protein 2 silencing.
Esfandiary A, Kutsche HS, Schreckenberg R, Weber M, Pak O, Kojonazarov B, Sydykov A, Hirschhäuser C, Wolf A, Haag D, Hecker M, Fink L, Seeger W, Ghofrani HA, Schermuly RT, Weißmann N, Schulz R, Rohrbach S, Li L, Sommer N, Schlüter KD. Esfandiary A, et al. Cardiovasc Res. 2019 Jun 1;115(7):1217-1227. doi: 10.1093/cvr/cvz049. Cardiovasc Res. 2019. PMID: 30850841 Free PMC article.
Lack of Contribution of p66shc to Pressure Overload-Induced Right Heart Hypertrophy.
Hirschhäuser C, Sydykov A, Wolf A, Esfandiary A, Bornbaum J, Kutsche HS, Boengler K, Sommer N, Schreckenberg R, Schlüter KD, Weissmann N, Schermuly R, Schulz R. Hirschhäuser C, et al. Among authors: esfandiary a. Int J Mol Sci. 2020 Dec 8;21(24):9339. doi: 10.3390/ijms21249339. Int J Mol Sci. 2020. PMID: 33302436 Free PMC article.
Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing.
Sommer N, Hüttemann M, Pak O, Scheibe S, Knoepp F, Sinkler C, Malczyk M, Gierhardt M, Esfandiary A, Kraut S, Jonas F, Veith C, Aras S, Sydykov A, Alebrahimdehkordi N, Giehl K, Hecker M, Brandes RP, Seeger W, Grimminger F, Ghofrani HA, Schermuly RT, Grossman LI, Weissmann N. Sommer N, et al. Among authors: esfandiary a. Circ Res. 2017 Aug 4;121(4):424-438. doi: 10.1161/CIRCRESAHA.116.310482. Epub 2017 Jun 15. Circ Res. 2017. PMID: 28620066 Free PMC article.
Mitochondrial hyperpolarization in pulmonary vascular remodeling. Mitochondrial uncoupling protein deficiency as disease model.
Pak O, Sommer N, Hoeres T, Bakr A, Waisbrod S, Sydykov A, Haag D, Esfandiary A, Kojonazarov B, Veit F, Fuchs B, Weisel FC, Hecker M, Schermuly RT, Grimminger F, Ghofrani HA, Seeger W, Weissmann N. Pak O, et al. Among authors: esfandiary a. Am J Respir Cell Mol Biol. 2013 Sep;49(3):358-67. doi: 10.1165/rcmb.2012-0361OC. Am J Respir Cell Mol Biol. 2013. PMID: 23590303