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Did you mean xin du (1,261 results)?
[Axin-2+ hepatocytes are better at maintaining liver mass].
Dollé L, Gilgenkrantz H. Dollé L, et al. Med Sci (Paris). 2015 Dec;31(12):1069-71. doi: 10.1051/medsci/20153112007. Epub 2015 Dec 16. Med Sci (Paris). 2015. PMID: 26672656 Free article. French. No abstract available.
Pinworm and TNKS inhibitors, an eccentric duo to derail the oncogenic WNT pathway.
Ouelaa-Benslama R, Emami S. Ouelaa-Benslama R, et al. Clin Res Hepatol Gastroenterol. 2011 Sep;35(8-9):534-8. doi: 10.1016/j.clinre.2011.03.015. Epub 2011 Jul 22. Clin Res Hepatol Gastroenterol. 2011. PMID: 21782548 Review.
The WNT/beta-catenin pathway underlies many human cancers through mutations in the APC, beta-catenin, and Axin genes. Activation of WNT signalling can also occur due to the localization of glycogen synthase kinase 3beta(GSK3beta) to the multivesicular bodies, which prevent …
The WNT/beta-catenin pathway underlies many human cancers through mutations in the APC, beta-catenin, and Axin genes. Activation of W …
[Advance in research on the correlation between genotypes of susceptible mutations and clinical phenotype of familial adenomatous polyposis].
He S, Du J, Liu F. He S, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017 Dec 10;34(6):919-923. doi: 10.3760/cma.j.issn.1003-9406.2017.06.031. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017. PMID: 29188631 Review. Chinese.
Potential gene modulation sites in patients who have typical clinical manifestations but with unidentified APC mutations are also discussed, which included MUTYH gene, AXIN gene and certain epigenetic changes. With the generalization of Precision Medicine, to offer individ …
Potential gene modulation sites in patients who have typical clinical manifestations but with unidentified APC mutations are also discussed, …
AXIN2 germline testing in a French cohort validates pathogenic variants as a rare cause of predisposition to colorectal polyposis and cancer.
Leclerc J, Beaumont M, Vibert R, Pinson S, Vermaut C, Flament C, Lovecchio T, Delattre L, Demay C, Coulet F, Guillerm E, Hamzaoui N, Benusiglio PR, Brahimi A, Cornelis F, Delhomelle H, Fert-Ferrer S, Fournier BPJ, Hovnanian A, Legrand C, Lortholary A, Malka D, Petit F, Saurin JC, Lejeune S, Colas C, Buisine MP. Leclerc J, et al. Genes Chromosomes Cancer. 2023 Apr;62(4):210-222. doi: 10.1002/gcc.23112. Epub 2022 Dec 21. Genes Chromosomes Cancer. 2023. PMID: 36502525 Free PMC article.
Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop.
Walter RJ, Sonnentag SJ, Munoz-Sagredo L, Merkel M, Richert L, Bunert F, Heneka YM, Loustau T, Hodder M, Ridgway RA, Sansom OJ, Mely Y, Rothbauer U, Schmitt M, Orian-Rousseau V. Walter RJ, et al. Cell Death Dis. 2022 Feb 21;13(2):168. doi: 10.1038/s41419-022-04607-0. Cell Death Dis. 2022. PMID: 35190527 Free PMC article.
We localized the molecular function of CD44 at the Wnt signalosome, and identified novel DVL/CD44 and AXIN/CD44 complexes. CD44 thus promotes optimal Wnt signaling during intestinal regeneration....
We localized the molecular function of CD44 at the Wnt signalosome, and identified novel DVL/CD44 and AXIN/CD44 complexes. CD44 thus …
A Context-Dependent Role for the RNF146 Ubiquitin Ligase in Wingless/Wnt Signaling in Drosophila.
Wang Z, Tacchelly-Benites O, Noble GP, Johnson MK, Gagné JP, Poirier GG, Ahmed Y. Wang Z, et al. Genetics. 2019 Mar;211(3):913-923. doi: 10.1534/genetics.118.301393. Epub 2018 Dec 28. Genetics. 2019. PMID: 30593492 Free PMC article.
Proteolysis of TNKS substrates is mediated through their ubiquitination by the poly-ADP-ribose (pADPr)-dependent RING-domain E3 ubiquitin ligase RNF146/Iduna. Like TNKS, RNF146 promotes Axin proteolysis and Wnt pathway activation in some cultured cell lines, but in contras …
Proteolysis of TNKS substrates is mediated through their ubiquitination by the poly-ADP-ribose (pADPr)-dependent RING-domain E3 ubiquitin li …
Yellow submarine of the Wnt/Frizzled signaling: submerging from the G protein harbor to the targets.
Koval A, Purvanov V, Egger-Adam D, Katanaev VL. Koval A, et al. Biochem Pharmacol. 2011 Nov 15;82(10):1311-9. doi: 10.1016/j.bcp.2011.06.005. Epub 2011 Jun 13. Biochem Pharmacol. 2011. PMID: 21689640 Review.
One group of these effectors is represented by small GTPases of the Rab family, which amplify the initial Wnt/Frizzled signal. Another effector is the negative regulator of Wnt signaling Axin, which becomes deactivated in response to Go action. The discovery of the GPCR pr …
One group of these effectors is represented by small GTPases of the Rab family, which amplify the initial Wnt/Frizzled signal. Another effec …
Rnf25/AO7 positively regulates wnt signaling via disrupting Nkd1-Axin inhibitory complex independent of its ubiquitin ligase activity.
Gao R, Ma LQ, Du X, Zhang TT, Zhao L, Liu L, Liu JC, Guo F, Cheng Z, Huang H. Gao R, et al. Oncotarget. 2016 Apr 26;7(17):23850-9. doi: 10.18632/oncotarget.8126. Oncotarget. 2016. PMID: 27007149 Free PMC article.
Here we report that Rnf25/AO7, a previously identified E3 ubiquitin ligase for Nkd2, physically interacts with Nkd1 and Axin in an E3 ligase-independent manner to strengthen Wnt signalling. ...Our results indicated that Rnf25 might serve as a molecular device, controlling …
Here we report that Rnf25/AO7, a previously identified E3 ubiquitin ligase for Nkd2, physically interacts with Nkd1 and Axin in an E3 …
Reversal of hyperactive Wnt signaling-dependent adipocyte defects by peptide boronic acids.
Zhang T, Hsu FN, Xie XJ, Li X, Liu M, Gao X, Pei X, Liao Y, Du W, Ji JY. Zhang T, et al. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7469-E7478. doi: 10.1073/pnas.1621048114. Epub 2017 Aug 21. Proc Natl Acad Sci U S A. 2017. PMID: 28827348 Free PMC article.
We have established a Drosophila model with hyperactivated Wnt signaling caused by partial loss of axin, a key component of the Wnt cascade. The Axin mutant larvae are transparent and have severe adipocyte defects caused by up-regulation of beta-catenin transcriptio …
We have established a Drosophila model with hyperactivated Wnt signaling caused by partial loss of axin, a key component of the Wnt c …
26 results