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The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic.
Kadosh E, Snir-Alkalay I, Venkatachalam A, May S, Lasry A, Elyada E, Zinger A, Shaham M, Vaalani G, Mernberger M, Stiewe T, Pikarsky E, Oren M, Ben-Neriah Y. Kadosh E, et al. Among authors: venkatachalam a. Nature. 2020 Oct;586(7827):133-138. doi: 10.1038/s41586-020-2541-0. Epub 2020 Jul 29. Nature. 2020. PMID: 32728212 Free PMC article.
Putative homeostatic role of cancer driver mutations.
Venkatachalam A, Pikarsky E, Ben-Neriah Y. Venkatachalam A, et al. Trends Cell Biol. 2022 Jan;32(1):8-17. doi: 10.1016/j.tcb.2021.07.002. Epub 2021 Aug 6. Trends Cell Biol. 2022. PMID: 34373150 Review.
Tissue-Predisposition to Cancer Driver Mutations.
Peters L, Venkatachalam A, Ben-Neriah Y. Peters L, et al. Among authors: venkatachalam a. Cells. 2024 Jan 5;13(2):106. doi: 10.3390/cells13020106. Cells. 2024. PMID: 38247798 Free PMC article. Review.
Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.
Minzel W, Venkatachalam A, Fink A, Hung E, Brachya G, Burstain I, Shaham M, Rivlin A, Omer I, Zinger A, Elias S, Winter E, Erdman PE, Sullivan RW, Fung L, Mercurio F, Li D, Vacca J, Kaushansky N, Shlush L, Oren M, Levine R, Pikarsky E, Snir-Alkalay I, Ben-Neriah Y. Minzel W, et al. Among authors: venkatachalam a. Cell. 2018 Sep 20;175(1):171-185.e25. doi: 10.1016/j.cell.2018.07.045. Epub 2018 Aug 23. Cell. 2018. PMID: 30146162 Free PMC article.
Atypical profiles and modulations of heme-enzymes catalyzed outcomes by low amounts of diverse additives suggest diffusible radicals' obligatory involvement in such redox reactions.
Manoj KM, Parashar A, Venkatachalam A, Goyal S, Satyalipsu, Singh PG, Gade SK, Periyasami K, Jacob RS, Sardar D, Singh S, Kumar R, Gideon DA. Manoj KM, et al. Among authors: venkatachalam a. Biochimie. 2016 Jun;125:91-111. doi: 10.1016/j.biochi.2016.03.003. Epub 2016 Mar 10. Biochimie. 2016. PMID: 26969799