PHA-680626 Is an Effective Inhibitor of the Interaction between Aurora-A and N-Myc.
Boi D, Souvalidou F, Capelli D, Polverino F, Marini G, Montanari R, Pochetti G, Tramonti A, Contestabile R, Trisciuoglio D, Carpinelli P, Ascanelli C, Lindon C, De Leo A, Saviano M, Di Santo R, Costi R, Guarguaglini G, Paiardini A.
Boi D, et al.
Int J Mol Sci. 2021 Dec 4;22(23):13122. doi: 10.3390/ijms222313122.
Int J Mol Sci. 2021.
PMID: 34884931
Free PMC article.
The amplification of the MYCN gene, coding for the N-Myc transcription factor, is an essential marker correlated with tumor progression and poor prognosis. In neuroblastoma cells, the mitotic kinase Aurora-A (AURKA), also frequently overexpressed in cancer, prevents N-Myc …
The amplification of the MYCN gene, coding for the N-Myc transcription factor, is an essential marker correlated with tumor progression and …