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[Hemocyanins as immunostimulants].
Del Campo M, Arancibia S, Nova E, Salazar F, González A, Moltedo B, De Ioannes P, Ferreira J, Manubens A, Becker MI. Del Campo M, et al. Among authors: manubens a. Rev Med Chil. 2011 Feb;139(2):236-46. Epub 2011 Jul 11. Rev Med Chil. 2011. PMID: 21773663 Free article. Review. Spanish.
The oxygen-binding properties of hemocyanin from the mollusk Concholepas concholepas.
González A, Nova E, Del Campo M, Manubens A, De Ioannes A, Ferreira J, Becker MI. González A, et al. Among authors: manubens a. Biochim Biophys Acta Proteins Proteom. 2017 Dec;1865(12):1746-1757. doi: 10.1016/j.bbapap.2017.08.017. Epub 2017 Aug 24. Biochim Biophys Acta Proteins Proteom. 2017. PMID: 28844742
Structural insights into a functional unit from an immunogenic mollusk hemocyanin.
Muñoz SM, Vallejos-Baccelliere G, Manubens A, Salazar ML, Nascimento AFZ, Tapia-Reyes P, Meneses C, Ambrosio ALB, Becker MI, Guixé V, Castro-Fernandez V. Muñoz SM, et al. Among authors: manubens a. Structure. 2024 Mar 14:S0969-2126(24)00057-1. doi: 10.1016/j.str.2024.02.018. Online ahead of print. Structure. 2024. PMID: 38513659
C-type lectin receptors MR and DC-SIGN are involved in recognition of hemocyanins, shaping their immunostimulatory effects on human dendritic cells.
Villar J, Salazar ML, Jiménez JM, Campo MD, Manubens A, Gleisner MA, Ávalos I, Salazar-Onfray F, Salazar F, Mitchell DA, Alshahrani MY, Martínez-Pomares L, Becker MI. Villar J, et al. Among authors: manubens a. Eur J Immunol. 2021 Jul;51(7):1715-1731. doi: 10.1002/eji.202149225. Epub 2021 May 6. Eur J Immunol. 2021. PMID: 33891704 Free article.
Surface immunogenic protein from Streptococcus agalactiae and Fissurella latimarginata hemocyanin are TLR4 ligands and activate MyD88- and TRIF dependent signaling pathways.
Díaz-Dinamarca DA, Salazar ML, Escobar DF, Castillo BN, Valdebenito B, Díaz P, Manubens A, Salazar F, Troncoso MF, Lavandero S, Díaz J, Becker MI, Vásquez AE. Díaz-Dinamarca DA, et al. Among authors: manubens a. Front Immunol. 2023 Sep 18;14:1186188. doi: 10.3389/fimmu.2023.1186188. eCollection 2023. Front Immunol. 2023. PMID: 37790926 Free PMC article.
TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells From Mammals.
Jiménez JM, Salazar ML, Arancibia S, Villar J, Salazar F, Brown GD, Lavelle EC, Martínez-Pomares L, Ortiz-Quintero J, Lavandero S, Manubens A, Becker MI. Jiménez JM, et al. Among authors: manubens a. Front Immunol. 2019 May 31;10:1136. doi: 10.3389/fimmu.2019.01136. eCollection 2019. Front Immunol. 2019. PMID: 31214162 Free PMC article.
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