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Showing results for athira one an
Search for Athita Onuean instead (1 results)
Lecanemab (BAN2401): an anti-beta-amyloid monoclonal antibody for the treatment of Alzheimer disease.
Vitek GE, Decourt B, Sabbagh MN. Vitek GE, et al. Expert Opin Investig Drugs. 2023 Feb;32(2):89-94. doi: 10.1080/13543784.2023.2178414. Epub 2023 Feb 28. Expert Opin Investig Drugs. 2023. PMID: 36749830 Free PMC article. Review.
The experience of aducanumab informs the development of other mAbs, such as lecanemab. One consideration is the conformation of Abeta targets. Targeting monomeric species has not resulted in robust clinical efficacy, whereas targeting Abeta in the form of oligomers, protof …
The experience of aducanumab informs the development of other mAbs, such as lecanemab. One consideration is the conformation of Abeta …
Results and insights from a phase I clinical trial of Lomecel-B for Alzheimer's disease.
Brody M, Agronin M, Herskowitz BJ, Bookheimer SY, Small GW, Hitchinson B, Ramdas K, Wishard T, McInerney KF, Vellas B, Sierra F, Jiang Z, Mcclain-Moss L, Perez C, Fuquay A, Rodriguez S, Hare JM, Oliva AA Jr, Baumel B. Brody M, et al. Alzheimers Dement. 2023 Jan;19(1):261-273. doi: 10.1002/alz.12651. Epub 2022 Mar 31. Alzheimers Dement. 2023. PMID: 35357079 Free PMC article. Clinical Trial.
One step forward to personalized medicine?
Dodge HH, Arnold SE. Dodge HH, et al. Alzheimers Dement (N Y). 2023 Nov 15;9(4):e12435. doi: 10.1002/trc2.12435. eCollection 2023 Oct-Dec. Alzheimers Dement (N Y). 2023. PMID: 38023621 Free PMC article. No abstract available.
Tilavonemab in early Alzheimer's disease: results from a phase 2, randomized, double-blind study.
Florian H, Wang D, Arnold SE, Boada M, Guo Q, Jin Z, Zheng H, Fisseha N, Kalluri HV, Rendenbach-Mueller B, Budur K, Gold M. Florian H, et al. Brain. 2023 Jun 1;146(6):2275-2284. doi: 10.1093/brain/awad024. Brain. 2023. PMID: 36730056 Free PMC article. Clinical Trial.
In this 96-week, randomized, double-blind, placebo-controlled study (NCT02880956), patients aged 55-85 years meeting clinical criteria for early Alzheimer's disease with a Clinical Dementia Rating-Global Score of 0.5, a Mini-Mental State Examination score of 22 to 30, a Repeatabl …
In this 96-week, randomized, double-blind, placebo-controlled study (NCT02880956), patients aged 55-85 years meeting clinical criteria for e …
Effect of Methylphenidate on Apathy in Patients With Alzheimer Disease: The ADMET 2 Randomized Clinical Trial.
Mintzer J, Lanctôt KL, Scherer RW, Rosenberg PB, Herrmann N, van Dyck CH, Padala PR, Brawman-Mintzer O, Porsteinsson AP, Lerner AJ, Craft S, Levey AI, Burke W, Perin J, Shade D; ADMET 2 Research Group. Mintzer J, et al. JAMA Neurol. 2021 Nov 1;78(11):1324-1332. doi: 10.1001/jamaneurol.2021.3356. JAMA Neurol. 2021. PMID: 34570180 Free PMC article. Clinical Trial.
IMPORTANCE: Apathy, characterized by diminished will or initiative and one of the most prevalent neuropsychiatric symptoms in individuals with Alzheimer disease, is associated with significant caregiver burden, excess disability, increased medical costs, and mortality. ...
IMPORTANCE: Apathy, characterized by diminished will or initiative and one of the most prevalent neuropsychiatric symptoms in individ …
ACU193: An Immunotherapeutic Poised to Test the Amyloid β Oligomer Hypothesis of Alzheimer's Disease.
Krafft GA, Jerecic J, Siemers E, Cline EN. Krafft GA, et al. Front Neurosci. 2022 Apr 26;16:848215. doi: 10.3389/fnins.2022.848215. eCollection 2022. Front Neurosci. 2022. PMID: 35557606 Free PMC article. Review.
Approved treatments confer modest improvement in symptoms, and recently one treatment obtained accelerated approval from the United States Food and Drug Administration (FDA) and may have modest disease modifying benefit. ...Aducanumab (targeting amyloid plaques), which rec …
Approved treatments confer modest improvement in symptoms, and recently one treatment obtained accelerated approval from the United S …
The effects of psilocybin on cognitive and emotional functions in healthy participants: Results from a phase 1, randomised, placebo-controlled trial involving simultaneous psilocybin administration and preparation.
Rucker JJ, Marwood L, Ajantaival RJ, Bird C, Eriksson H, Harrison J, Lennard-Jones M, Mistry S, Saldarini F, Stansfield S, Tai SJ, Williams S, Weston N, Malievskaia E, Young AH. Rucker JJ, et al. J Psychopharmacol. 2022 Jan;36(1):114-125. doi: 10.1177/02698811211064720. Epub 2022 Jan 4. J Psychopharmacol. 2022. PMID: 35090363 Free PMC article. Clinical Trial.
METHODS: In this phase 1, randomised, double-blind, placebo-controlled study, healthy participants (n = 89; mean age 36.1 years; 41 females, 48 males) were randomised to receive a single oral dose of 10 or 25 mg psilocybin, or placebo, administered simultaneously to up to six par …
METHODS: In this phase 1, randomised, double-blind, placebo-controlled study, healthy participants (n = 89; mean age 36.1 years; 41 females, …
Diagnostic criteria for apathy in neurocognitive disorders.
Miller DS, Robert P, Ereshefsky L, Adler L, Bateman D, Cummings J, DeKosky ST, Fischer CE, Husain M, Ismail Z, Jaeger J, Lerner AJ, Li A, Lyketsos CG, Manera V, Mintzer J, Moebius HJ, Mortby M, Meulien D, Pollentier S, Porsteinsson A, Rasmussen J, Rosenberg PB, Ruthirakuhan MT, Sano M, Zucchero Sarracini C, Lanctôt KL. Miller DS, et al. Alzheimers Dement. 2021 Dec;17(12):1892-1904. doi: 10.1002/alz.12358. Epub 2021 May 5. Alzheimers Dement. 2021. PMID: 33949763 Free PMC article.
RESULTS: The final criteria reached consensus with more than 80% agreement on all parts and included: limited to people with NCD; symptoms persistent or frequently recurrent over at least 4 weeks, a change from the patient's usual behavior, and including one of the followi …
RESULTS: The final criteria reached consensus with more than 80% agreement on all parts and included: limited to people with NCD; symptoms p …
Pyrogens, a polypeptide produces fever by metabolic changes in hypothalamus: Mechanisms and detections.
Prajitha N, Athira SS, Mohanan PV. Prajitha N, et al. Immunol Lett. 2018 Dec;204:38-46. doi: 10.1016/j.imlet.2018.10.006. Epub 2018 Oct 15. Immunol Lett. 2018. PMID: 30336182 Review.
Fever is one of the cardinal symptoms of onset of an infection or inflammation and is the common clinical indicator for medical consultation in mammalian host worldwide. ...
Fever is one of the cardinal symptoms of onset of an infection or inflammation and is the common clinical indicator for medical consu …
A CBCT Study to Evaluate the Root and Canal Morphology of Permanent Maxillary First Molars in Children.
Krishnamurthy NH, Athira P, Umapathy T, Balaji P, Jose S. Krishnamurthy NH, et al. Int J Clin Pediatr Dent. 2022 Sep-Oct;15(5):509-513. doi: 10.5005/jp-journals-10005-2441. Int J Clin Pediatr Dent. 2022. PMID: 36865715 Free PMC article.
INTRODUCTION: For the correct diagnosis and endodontic therapy, a complete understanding of root canal morphology is required. One of the causes of endodontic failure is the inability to identify every canal in the root canal system; the second mesiobuccal canal (MB2) in t …
INTRODUCTION: For the correct diagnosis and endodontic therapy, a complete understanding of root canal morphology is required. One of …
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