Aptamer-Based Biosensors for Antibiotic Detection: A Review

Biosensors (Basel). 2018 Jun 11;8(2):54. doi: 10.3390/bios8020054.

Abstract

Antibiotic resistance and, accordingly, their pollution because of uncontrolled usage has emerged as a serious problem in recent years. Hence, there is an increased demand to develop robust, easy, and sensitive methods for rapid evaluation of antibiotics and their residues. Among different analytical methods, the aptamer-based biosensors (aptasensors) have attracted considerable attention because of good selectivity, specificity, and sensitivity. This review gives an overview about recently-developed aptasensors for antibiotic detection. The use of various aptamer assays to determine different groups of antibiotics, like β-lactams, aminoglycosides, anthracyclines, chloramphenicol, (fluoro)quinolones, lincosamide, tetracyclines, and sulfonamides are presented in this paper.

Keywords: ampicillin; antibiotic; aptamer; aptasensor; biosensor; chloramphenicol; ciprofloxacin; danofloxacin; daunomycin; enrofloxacin; gentamicin; kanamycin; lincomycin; neomycin; ofloxacin; oxytetracycline; penicillin; streptomycin; sulfadimethoxine; tetracycline; tobramycin.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Aptamers, Peptide / pharmacology
  • Aptamers, Peptide / therapeutic use*
  • Biosensing Techniques / methods*
  • Humans

Substances

  • Anti-Bacterial Agents
  • Aptamers, Peptide