Albumin Stabilized Fe@C Core-Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

Maria Antonieta Ramírez-Morales; Anastasia E Goldt; Polina M Kalachikova; Javier A Ramirez B; Masashi Suzuki; Alexey N Zhigach; Asma Ben Salah; Liliya I Shurygina; Sergey D Shandakov; Timofei Zatsepin; Dmitry V Krasnikov; Toru Maekawa; Evgeny N Nikolaev; Albert G Nasibulin

doi:10.3390/nano12162869

Albumin Stabilized Fe@C Core-Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

Nanomaterials (Basel). 2022 Aug 20;12(16):2869. doi: 10.3390/nano12162869.

Authors

Maria Antonieta Ramírez-Morales^{1

2

3}, Anastasia E Goldt¹, Polina M Kalachikova^{1

4}, Javier A Ramirez B¹, Masashi Suzuki^{5

6}, Alexey N Zhigach⁷, Asma Ben Salah^{5

6}, Liliya I Shurygina⁸, Sergey D Shandakov⁸, Timofei Zatsepin¹, Dmitry V Krasnikov¹, Toru Maekawa^{5

6}, Evgeny N Nikolaev¹, Albert G Nasibulin^{1

4}

Affiliations

¹ Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia.
² Hi-QNano s.r.l., Via Barsanti No. 1, 73010 Arnesano, Italy.
³ Department of Engineering of Innovation, University of Salento, Via per Arnesano km 1, 73100 Lecce, Italy.
⁴ School of Chemical Engineering, Aalto University, Kemistintie 1, 02015 Espoo, Finland.
⁵ Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe 350-8585, Saitama, Japan.
⁶ Bio-Nano Electronics Research Center, Toyo University, Kawagoe 350-8585, Saitama, Japan.
⁷ V.L. Talrose Institute for Energy Problems of Chemical Physics at Federal Research Center of Chemical Physics, Russian Academy of Sciences, Leninsky Prospect 38 Building 2, 119334 Moscow, Russia.
⁸ Kemerovo State University, Krasnaya 6, 650043 Kemerovo, Russia.

Abstract

Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation-condensation flow-levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their electromagnetic properties were evaluated to test their performance in magnetic hyperthermia therapy (MHT) through a specific absorption rate (SAR). Heat generation was observed at different Fe@C concentrations (1, 2.5, and 5 mg/mL) when applied 331 kHz and 60 kA/m of an alternating magnetic field, resulting in SAR values of 437.64, 129.36, and 50.4 W/g for each concentration, respectively. Having such high SAR values at low concentrations, obtained material is ideal for use in MHT.

Keywords: core–shell nanoparticles; ferromagnetic particles; flow-levitation method; iron nanoparticles; magnetic hyperthermia.

Abstract

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