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Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET.
Kanellis DC, Zisi A, Skrott Z, Lemmens B, Espinoza JA, Kosar M, Björkman A, Li X, Arampatzis S, Bartkova J, Andújar-Sánchez M, Fernandez-Capetillo O, Mistrik M, Lindström MS, Bartek J. Kanellis DC, et al. Among authors: zisi a. Cell Death Differ. 2023 Jul;30(7):1666-1678. doi: 10.1038/s41418-023-01167-4. Epub 2023 May 4. Cell Death Differ. 2023. PMID: 37142656 Free PMC article.
The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output.
Kanellis DC, Espinoza JA, Zisi A, Sakkas E, Bartkova J, Katsori AM, Boström J, Dyrskjøt L, Broholm H, Altun M, Elsässer SJ, Lindström MS, Bartek J. Kanellis DC, et al. Among authors: zisi a. Sci Adv. 2021 Aug 4;7(32):eabf7561. doi: 10.1126/sciadv.abf7561. Print 2021 Aug. Sci Adv. 2021. PMID: 34348895 Free PMC article.