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1,608 results

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Page 1
Showing results for ashley cells
Search for Ashley Celis instead (2 results)
Colonic epithelial cell diversity in health and inflammatory bowel disease.
Parikh K, Antanaviciute A, Fawkner-Corbett D, Jagielowicz M, Aulicino A, Lagerholm C, Davis S, Kinchen J, Chen HH, Alham NK, Ashley N, Johnson E, Hublitz P, Bao L, Lukomska J, Andev RS, Björklund E, Kessler BM, Fischer R, Goldin R, Koohy H, Simmons A. Parikh K, et al. Nature. 2019 Mar;567(7746):49-55. doi: 10.1038/s41586-019-0992-y. Epub 2019 Feb 27. Nature. 2019. PMID: 30814735 Free article.
However, the specific contributions of each epithelial-cell subtype to this process are unknown. Here we profile single colonic epithelial cells from patients with IBD and unaffected controls. We identify previously unknown cellular subtypes, including gradients of progeni …
However, the specific contributions of each epithelial-cell subtype to this process are unknown. Here we profile single colonic epithelial …
Spatiotemporal analysis of human intestinal development at single-cell resolution.
Fawkner-Corbett D, Antanaviciute A, Parikh K, Jagielowicz M, Gerós AS, Gupta T, Ashley N, Khamis D, Fowler D, Morrissey E, Cunningham C, Johnson PRV, Koohy H, Simmons A. Fawkner-Corbett D, et al. Cell. 2021 Feb 4;184(3):810-826.e23. doi: 10.1016/j.cell.2020.12.016. Epub 2021 Jan 5. Cell. 2021. PMID: 33406409 Free PMC article.
We identify the differentiation hierarchies of developing fibroblast and myofibroblast subtypes and describe diverse functions for these including as vascular niche cells. We pinpoint the origins of Peyer's patches and gut-associated lymphoid tissue (GALT) and describe loc …
We identify the differentiation hierarchies of developing fibroblast and myofibroblast subtypes and describe diverse functions for these inc …
Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease.
Kinchen J, Chen HH, Parikh K, Antanaviciute A, Jagielowicz M, Fawkner-Corbett D, Ashley N, Cubitt L, Mellado-Gomez E, Attar M, Sharma E, Wills Q, Bowden R, Richter FC, Ahern D, Puri KD, Henault J, Gervais F, Koohy H, Simmons A. Kinchen J, et al. Cell. 2018 Oct 4;175(2):372-386.e17. doi: 10.1016/j.cell.2018.08.067. Epub 2018 Sep 27. Cell. 2018. PMID: 30270042 Free PMC article.
Intestinal mesenchymal cells play essential roles in epithelial homeostasis, matrix remodeling, immunity, and inflammation. ...Using unbiased single-cell profiling of over 16,500 colonic mesenchymal cells, we reveal four subsets of fibroblasts expressing divergent t …
Intestinal mesenchymal cells play essential roles in epithelial homeostasis, matrix remodeling, immunity, and inflammation. ...Using …
Mucosal plasma cells are required to protect the upper airway and brain from infection.
Wellford SA, Moseman AP, Dao K, Wright KE, Chen A, Plevin JE, Liao TC, Mehta N, Moseman EA. Wellford SA, et al. Immunity. 2022 Nov 8;55(11):2118-2134.e6. doi: 10.1016/j.immuni.2022.08.017. Epub 2022 Sep 21. Immunity. 2022. PMID: 36137543 Free PMC article.
Using passive antibody transfers and parabiosis, we identified a restrictive blood-endothelial barrier that excluded circulating antibodies from the olfactory mucosa. Plasma cell depletions demonstrated that plasma cells must reside within olfactory tissue to achieve steri …
Using passive antibody transfers and parabiosis, we identified a restrictive blood-endothelial barrier that excluded circulating antibodies …
Cellular biology of fracture healing.
Bahney CS, Zondervan RL, Allison P, Theologis A, Ashley JW, Ahn J, Miclau T, Marcucio RS, Hankenson KD. Bahney CS, et al. J Orthop Res. 2019 Jan;37(1):35-50. doi: 10.1002/jor.24170. Epub 2018 Nov 30. J Orthop Res. 2019. PMID: 30370699 Free PMC article. Review.
Herein, cells that play a key role in bone healing will be reviewed and extracellular mediators regulating their behavior discussed. We will focus on recent studies that explore novel roles of inflammation in bone healing, and the origins and fates of various cells …
Herein, cells that play a key role in bone healing will be reviewed and extracellular mediators regulating their behavior discussed. …
The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases.
DeMaio A, Mehrotra S, Sambamurti K, Husain S. DeMaio A, et al. J Neuroinflammation. 2022 Oct 8;19(1):251. doi: 10.1186/s12974-022-02605-9. J Neuroinflammation. 2022. PMID: 36209107 Free PMC article. Review.
However, T cell involvement and the disruption of the blood-brain barriers have been linked to several neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, and multiple sclerosis. Under normal physiological conditions, regulatory T cells (Treg …
However, T cell involvement and the disruption of the blood-brain barriers have been linked to several neurodegenerative diseases including …
New perspectives on the origins and heterogeneity of mast cells.
St John AL, Rathore APS, Ginhoux F. St John AL, et al. Nat Rev Immunol. 2023 Jan;23(1):55-68. doi: 10.1038/s41577-022-00731-2. Epub 2022 May 24. Nat Rev Immunol. 2023. PMID: 35610312 Review.
Mast cells are immune cells of the haematopoietic lineage that are now thought to have multifaceted functions during homeostasis and in various disease states. ...Here, we discuss the origins of mast cells and their diverse and plastic phenotypes that are inf …
Mast cells are immune cells of the haematopoietic lineage that are now thought to have multifaceted functions during homeostas …
Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons.
Ashley J, Cordy B, Lucia D, Fradkin LG, Budnik V, Thomson T. Ashley J, et al. Cell. 2018 Jan 11;172(1-2):262-274.e11. doi: 10.1016/j.cell.2017.12.022. Cell. 2018. PMID: 29328915 Free PMC article.
Disrupting transfer blocks synaptic plasticity, suggesting that transfer of dArc1 complexed with its mRNA is required for this function. Notably, cultured cells also release extracellular vesicles containing the Gag region of the Copia retrotransposon complexed with its ow …
Disrupting transfer blocks synaptic plasticity, suggesting that transfer of dArc1 complexed with its mRNA is required for this function. Not …
Plasticity of hematopoietic stem cells.
Ogawa M, LaRue AC, Mehrotra M. Ogawa M, et al. Best Pract Res Clin Haematol. 2015 Jun-Sep;28(2-3):73-80. doi: 10.1016/j.beha.2015.10.003. Epub 2015 Oct 22. Best Pract Res Clin Haematol. 2015. PMID: 26590762 Review.
Almost two decades ago, a number of cell culture and preclinical transplantation studies suggested the striking concept of the tissue-reconstituting ability of hematopoietic stem cells (HSCs). While this heralded an exciting time of radically new therapies for disorders of …
Almost two decades ago, a number of cell culture and preclinical transplantation studies suggested the striking concept of the tissue-recons …
1,608 results