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The following terms were not found in PubMed: Kurniyawan, Hardjana
Page 1
Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy.
Yang X, Zhong J, Zhang Q, Feng L, Zheng Z, Zhang J, Lu S. Yang X, et al. Front Mol Biosci. 2021 Apr 22;8:662579. doi: 10.3389/fmolb.2021.662579. eCollection 2021. Front Mol Biosci. 2021. PMID: 33968990 Free PMC article. Review.
Knockdown of either APC or Asef significantly decreases the migration of CRC cells. Therefore, disrupting the APC-Asef interaction is a promising strategy for the treatment of invasive CRC. ...Here, we will review the APC-Asef interaction in cancer biology, t …
Knockdown of either APC or Asef significantly decreases the migration of CRC cells. Therefore, disrupting the APC-Asef interac …
The ASEF: "Together, We Can Make a World of Difference!".
Kirkpatrick JN, Little SH. Kirkpatrick JN, et al. J Am Soc Echocardiogr. 2023 Feb;36(2):A13-A14. doi: 10.1016/j.echo.2022.12.005. J Am Soc Echocardiogr. 2023. PMID: 36739139 No abstract available.
Truncated Adenomatous Polyposis Coli Mutation Induces Asef-Activated Golgi Fragmentation.
Kim SB, Zhang L, Yoon J, Lee J, Min J, Li W, Grishin NV, Moon YA, Wright WE, Shay JW. Kim SB, et al. Mol Cell Biol. 2018 Aug 15;38(17):e00135-18. doi: 10.1128/MCB.00135-18. Print 2018 Sep 1. Mol Cell Biol. 2018. PMID: 29866653 Free PMC article.
In colorectal cancers, while truncated APC constitutively activates Asef and promotes cancer initiation and progression, regulation of Asef by full-length APC is still unclear. ...We found that the armadillo repeats in full-length APC interact with the APC residues …
In colorectal cancers, while truncated APC constitutively activates Asef and promotes cancer initiation and progression, regulation o …
Average saturation efficiency filter ASEF-CEST MRI of stroke rodents.
Chung JJ, Jin T. Chung JJ, et al. Magn Reson Med. 2023 Feb;89(2):565-576. doi: 10.1002/mrm.29463. Epub 2022 Oct 27. Magn Reson Med. 2023. PMID: 36300851 Free PMC article.
PURPOSE: The average saturation efficiency filter (ASEF) is a novel method of improving the specificity of CEST; however, there is a mismatch between the magnetization transfer (MT) effect under high-duty cycle and low-duty cycle pulse trains. We explore measures of mitiga …
PURPOSE: The average saturation efficiency filter (ASEF) is a novel method of improving the specificity of CEST; however, there is a …
Average saturation efficiency filter (ASEF) for CEST imaging.
Jin T, Chung JJ. Jin T, et al. Magn Reson Med. 2022 Jul;88(1):254-265. doi: 10.1002/mrm.29211. Epub 2022 Mar 28. Magn Reson Med. 2022. PMID: 35344594 Free PMC article.
We propose to improve CEST signal specificity with an average saturation efficiency filter (ASEF). METHODS: ASEF measures the difference between CEST signals acquired with similar average irradiation power but largely different duty cycles (DC), for example, a conti …
We propose to improve CEST signal specificity with an average saturation efficiency filter (ASEF). METHODS: ASEF measures the …
Structural basis for the recognition of Asef by adenomatous polyposis coli.
Zhang Z, Chen L, Gao L, Lin K, Zhu L, Lu Y, Shi X, Gao Y, Zhou J, Xu P, Zhang J, Wu G. Zhang Z, et al. Cell Res. 2012 Feb;22(2):372-86. doi: 10.1038/cr.2011.119. Epub 2011 Jul 26. Cell Res. 2012. PMID: 21788986 Free PMC article.
In colorectal cancers, truncated APC constitutively activates Asef and promotes cancer cell migration and angiogenesis. Here, we report crystal structures of the human APC/Asef complex. ...Structural superimposition of the APC/Asef complex with autoinhibited …
In colorectal cancers, truncated APC constitutively activates Asef and promotes cancer cell migration and angiogenesis. Here, we repo …
Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Jiang H, Deng R, Yang X, Shang J, Lu S, Zhao Y, Song K, Liu X, Zhang Q, Chen Y, Chinn YE, Wu G, Li J, Chen G, Yu J, Zhang J. Jiang H, et al. Nat Chem Biol. 2017 Sep;13(9):994-1001. doi: 10.1038/nchembio.2442. Epub 2017 Jul 24. Nat Chem Biol. 2017. PMID: 28759015
The binding of adenomatous polyposis coli (APC) to its receptor Asef relieves the negative intramolecular regulation of Asef and leads to aberrant cell migration in human colorectal cancer. ...Our work demonstrates the feasibility of exploiting APC-Asef inter …
The binding of adenomatous polyposis coli (APC) to its receptor Asef relieves the negative intramolecular regulation of Asef a …
Design, synthesis and biological evaluation of 2-H pyrazole derivatives containing morpholine moieties as highly potent small molecule inhibitors of APC-Asef interaction.
Yan XQ, Wang ZC, Qi PF, Li G, Zhu HL. Yan XQ, et al. Eur J Med Chem. 2019 Sep 1;177:425-447. doi: 10.1016/j.ejmech.2019.05.056. Epub 2019 May 26. Eur J Med Chem. 2019. PMID: 31158755 Review.
Mutated adenomatous polyposis coli (APC) selectively combining with Asef has been reported to be implicated in promoting colon cancer proliferation, invasion and metastasis in several cancer biotherapy studies. ...Afterwards they were evaluated interaction inhibition of AP …
Mutated adenomatous polyposis coli (APC) selectively combining with Asef has been reported to be implicated in promoting colon cancer …
Microtubules-associated Rac regulation of endothelial barrier: a role of Asef in acute lung injury.
Karki P, Birukova AA. Karki P, et al. J Investig Med. 2017 Dec;65(8):1089-1092. doi: 10.1136/jim-2017-000571. Epub 2017 Sep 18. J Investig Med. 2017. PMID: 28923883 Review.
In this regard, our recent studies have revealed some novel aspects of microtubules-mediated regulation of endothelial barrier functions and unraveled a putative role of Rac-specific guanine nucleotide exchange factor Asef in mediating the barrier protective effects of hep …
In this regard, our recent studies have revealed some novel aspects of microtubules-mediated regulation of endothelial barrier functions and …
Rational design of a sensitivity-enhanced tracer for discovering efficient APC-Asef inhibitors.
Zhong J, Guo Y, Lu S, Song K, Wang Y, Feng L, Zheng Z, Zhang Q, Wei J, Sang P, Shi Y, Cai J, Chen G, Liu CY, Yang X, Zhang J. Zhong J, et al. Nat Commun. 2022 Aug 24;13(1):4961. doi: 10.1038/s41467-022-32612-6. Nat Commun. 2022. PMID: 36002443 Free PMC article.
The adenomatous polyposis coli (APC)-Rho guanine nucleotide exchange factor 4 (Asef) protein-protein interaction (PPI) is essential for colorectal cancer metastasis, making it a promising drug target. ...MAIT-516 inhibits CRC cell migration by specifically hindering the AP …
The adenomatous polyposis coli (APC)-Rho guanine nucleotide exchange factor 4 (Asef) protein-protein interaction (PPI) is essential f …
106 results