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Biological Markers to Predict Outcome in Mechanically Ventilated Patients with Severe COVID-19 Living at High Altitude.
Vélez-Páez JL, Pelosi P, Battaglini D, Best I. Vélez-Páez JL, et al. J Clin Med. 2023 Jan 13;12(2):644. doi: 10.3390/jcm12020644. J Clin Med. 2023. PMID: 36675573 Free PMC article.
METHODS: We performed a retrospective observational study including patients with severe COVID-19, under mechanical ventilation and admitted to the intensive care unit (ICU) located at 2850 m above sea level, between 1 April 2020 and 1 August 2021. Inflammatory (interleuki …
METHODS: We performed a retrospective observational study including patients with severe COVID-19, under mechanical ventilation and admitted …
Long-Term Intermittent Work at High Altitude: Right Heart Functional and Morphological Status and Associated Cardiometabolic Factors.
Brito J, Siques P, López R, Romero R, León-Velarde F, Flores K, Lüneburg N, Hannemann J, Böger RH. Brito J, et al. Front Physiol. 2018 Mar 22;9:248. doi: 10.3389/fphys.2018.00248. eCollection 2018. Front Physiol. 2018. PMID: 29623044 Free PMC article.
Methods: A cross-sectional study of 120 healthy miners working at an altitude of 4,400-4,800 m for over 5 years in 7-day commuting shifts was designed. Echocardiography was performed on day 2 at sea level. ...
Methods: A cross-sectional study of 120 healthy miners working at an altitude of 4,400-4,800 m for over 5 years in 7-day commuting sh …
Adventitial alterations are the main features in pulmonary artery remodeling due to long-term chronic intermittent hypobaric hypoxia in rats.
Brito J, Siques P, Arribas SM, López de Pablo AL, González MC, Naveas N, Arriaza K, Flores K, León-Velarde F, Pulido R, Ordenes S, López MR. Brito J, et al. Biomed Res Int. 2015;2015:169841. doi: 10.1155/2015/169841. Epub 2015 Feb 8. Biomed Res Int. 2015. PMID: 25738150 Free PMC article.
Rats were subjected to chronic hypoxia (CH, n = 9) and long-term intermittent hypoxia (CIH2x2; 2 days of hypoxia/2 days of normoxia, n = 10) in a chamber (428 Torr, 4,600 m of altitude) for 46 days and compared to rats under normoxia (NX, n = 10). ...
Rats were subjected to chronic hypoxia (CH, n = 9) and long-term intermittent hypoxia (CIH2x2; 2 days of hypoxia/2 days of normoxia, n = 10) …
Lower Body Weight in Rats Under Hypobaric Hypoxia Exposure Would Lead to Reduced Right Ventricular Hypertrophy and Increased AMPK Activation.
Flores K, Siques P, Brito J, Ordenes S, Arriaza K, Pena E, León-Velarde F, López R, López de Pablo ÁL, Arribas S. Flores K, et al. Front Physiol. 2020 Apr 20;11:342. doi: 10.3389/fphys.2020.00342. eCollection 2020. Front Physiol. 2020. PMID: 32372974 Free PMC article.
Rats were exposed to simulated hypobaric hypoxia in a hypobaric chamber set to 428 Torr (the equivalent pressure to that at an altitude of 4,600 m above sea level) for 30 days. Measurements included body weight; hematocrit; serum insulin; glycemia; the degree of RVH (Fulto …
Rats were exposed to simulated hypobaric hypoxia in a hypobaric chamber set to 428 Torr (the equivalent pressure to that at an altitude of 4 …
Long-Term Chronic Intermittent Hypobaric Hypoxia Induces Glucose Transporter (GLUT4) Translocation Through AMP-Activated Protein Kinase (AMPK) in the Soleus Muscle in Lean Rats.
Siques P, Brito J, Flores K, Ordenes S, Arriaza K, Pena E, León-Velarde F, López de Pablo ÁL, Gonzalez MC, Arribas S. Siques P, et al. Front Physiol. 2018 Jun 28;9:799. doi: 10.3389/fphys.2018.00799. eCollection 2018. Front Physiol. 2018. PMID: 30002630 Free PMC article.
Rats were exposed to hypoxia for 30 days in a hypobaric chamber set at 428 Torr (4,600 m). Feeding (10 g daily) and fasting times were accurately controlled. ...
Rats were exposed to hypoxia for 30 days in a hypobaric chamber set at 428 Torr (4,600 m). Feeding (10 g daily) and fasting times wer …
Long-Term Intermittent Exposure to High Altitude Elevates Asymmetric Dimethylarginine in First Exposed Young Adults.
Lüneburg N, Siques P, Brito J, De La Cruz JJ, León-Velarde F, Hannemann J, Ibanez C, Böger RH. Lüneburg N, et al. High Alt Med Biol. 2017 Sep;18(3):226-233. doi: 10.1089/ham.2016.0123. Epub 2017 Apr 28. High Alt Med Biol. 2017. PMID: 28453332 Free PMC article.
We measured asymmetric and symmetric dimethylarginine (ADMA and SDMA) and monomethyl-L-arginine (L-NMMA) and assessed their associations with acclimatization in male draftees (n = 72) undergoing CIH shifts at altitude (3550 m) during 3 months. Sixteen Andean natives living …
We measured asymmetric and symmetric dimethylarginine (ADMA and SDMA) and monomethyl-L-arginine (L-NMMA) and assessed their associations wit …
Asymmetric Dimethylarginine at Sea Level Is a Predictive Marker of Hypoxic Pulmonary Arterial Hypertension at High Altitude.
Siques P, Brito J, Schwedhelm E, Pena E, León-Velarde F, De La Cruz JJ, Böger RH, Hannemann J. Siques P, et al. Front Physiol. 2019 May 27;10:651. doi: 10.3389/fphys.2019.00651. eCollection 2019. Front Physiol. 2019. PMID: 31191349 Free PMC article.
Methods: In this prospective study, 123 healthy army draftees were subjected to CIH (5 days at 3,550 m, 2 days at sea level) for 6 months. In 100 study participants with complete data, ADMA, symmetric dimethylarginine (SDMA), L-arginine, arterial oxygen saturation (SaO(2)) …
Methods: In this prospective study, 123 healthy army draftees were subjected to CIH (5 days at 3,550 m, 2 days at sea level) for 6 mo …