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Spermine and spermidine bind CXCR4 and inhibit CXCR4- but not CCR5-tropic HIV-1 infection.
Harms M, Smith N, Han M, Groß R, von Maltitz P, Stürzel C, Ruiz-Blanco YB, Almeida-Hernández Y, Rodriguez-Alfonso A, Cathelin D, Caspar B, Tahar B, Sayettat S, Bekaddour N, Vanshylla K, Kleipass F, Wiese S, Ständker L, Klein F, Lagane B, Boonen A, Schols D, Benichou S, Sanchez-Garcia E, Herbeuval JP, Münch J. Harms M, et al. Among authors: boonen a. Sci Adv. 2023 Jul 7;9(27):eadf8251. doi: 10.1126/sciadv.adf8251. Epub 2023 Jul 5. Sci Adv. 2023. PMID: 37406129 Free PMC article.
Multivalent Tryptophan- and Tyrosine-Containing [60]Fullerene Hexa-Adducts as Dual HIV and Enterovirus A71 Entry Inhibitors.
Ruiz-Santaquiteria M, Illescas BM, Abdelnabi R, Boonen A, Mills A, Martí-Marí O, Noppen S, Neyts J, Schols D, Gago F, San-Félix A, Camarasa MJ, Martín N. Ruiz-Santaquiteria M, et al. Among authors: boonen a. Chemistry. 2021 Jul 21;27(41):10700-10710. doi: 10.1002/chem.202101098. Epub 2021 Jun 1. Chemistry. 2021. PMID: 33851758 Free PMC article.
Targeted disruption of pi-pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity.
Covés-Datson EM, King SR, Legendre M, Swanson MD, Gupta A, Claes S, Meagher JL, Boonen A, Zhang L, Kalveram B, Raglow Z, Freiberg AN, Prichard M, Stuckey JA, Schols D, Markovitz DM. Covés-Datson EM, et al. Among authors: boonen a. Sci Rep. 2021 Jan 12;11(1):656. doi: 10.1038/s41598-020-80577-7. Sci Rep. 2021. PMID: 33436903 Free PMC article.
Double Arylation of the Indole Side Chain of Tri- and Tetrapodal Tryptophan Derivatives Renders Highly Potent HIV-1 and EV-A71 Entry Inhibitors†.
Martí-Marí O, Martínez-Gualda B, de la Puente-Secades S, Mills A, Quesada E, Abdelnabi R, Sun L, Boonen A, Noppen S, Neyts J, Schols D, Camarasa MJ, Gago F, San-Félix A. Martí-Marí O, et al. Among authors: boonen a. J Med Chem. 2021 Jul 22;64(14):10027-10046. doi: 10.1021/acs.jmedchem.1c00315. Epub 2021 Jul 7. J Med Chem. 2021. PMID: 34229438 Free PMC article.