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Bispecific antibodies in oncology.
Esfandiari A, Cassidy S, Webster RM. Esfandiari A, et al. Nat Rev Drug Discov. 2022 Jun;21(6):411-412. doi: 10.1038/d41573-022-00040-2. Nat Rev Drug Discov. 2022. PMID: 35246638 No abstract available.
Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody-Drug Conjugate Efficacy and Toxicity.
Tiberghien AC, Vijayakrishnan B, Esfandiari A, Ahmed M, Pardo R, Bingham J, Adams L, Santos K, Kang GD, Pugh KM, Afif-Rider S, Vashisht K, Haque K, Tammali R, Rosfjord E, Savoca A, Hartley JA, Howard PW. Tiberghien AC, et al. Among authors: esfandiari a. Mol Cancer Ther. 2023 Feb 1;22(2):254-263. doi: 10.1158/1535-7163.MCT-21-0693. Mol Cancer Ther. 2023. PMID: 36722141
TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation.
Drummond CJ, Esfandiari A, Liu J, Lu X, Hutton C, Jackson J, Bennaceur K, Xu Q, Makimanejavali AR, Del Bello F, Piergentili A, Newell DR, Hardcastle IR, Griffin RJ, Lunec J. Drummond CJ, et al. Among authors: esfandiari a. Oncotarget. 2016 Jul 19;7(29):46203-46218. doi: 10.18632/oncotarget.10073. Oncotarget. 2016. PMID: 27323823 Free PMC article.
MEK inhibition leads to BRCA2 downregulation and sensitization to DNA damaging agents in pancreas and ovarian cancer models.
Vena F, Jia R, Esfandiari A, Garcia-Gomez JJ, Rodriguez-Justo M, Ma J, Syed S, Crowley L, Elenbaas B, Goodstal S, Hartley JA, Hochhauser D. Vena F, et al. Among authors: esfandiari a. Oncotarget. 2018 Jan 22;9(14):11592-11603. doi: 10.18632/oncotarget.24294. eCollection 2018 Feb 20. Oncotarget. 2018. PMID: 29545922 Free PMC article.