Mucociliary clearance augmenting drugs block SARS-CoV-2 replication in human airway epithelial cells.
Campos-Gómez J, Fernandez Petty C, Mazur M, Tang L, Solomon GM, Joseph R, Li Q, Peabody Lever JE, Hussain SS, Harrod KS, Onuoha EE, Kim H, Rowe SM.
Campos-Gómez J, et al.
Am J Physiol Lung Cell Mol Physiol. 2023 Apr 1;324(4):L493-L506. doi: 10.1152/ajplung.00285.2022. Epub 2023 Feb 21.
Am J Physiol Lung Cell Mol Physiol. 2023.
PMID: 36809189
Free PMC article.
ARINA-1 antiviral activity was dependent on enhancing the MCT cellular response, since terminal differentiation, intact ciliary expression, and motion were required for ARINA-1-mediated anti-SARS-CoV2 protection. Ultimately, we showed that the improvement of cilia m …
ARINA-1 antiviral activity was dependent on enhancing the MCT cellular response, since terminal differentiation, intact ciliary expre …