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Randomized Trial of Empagliflozin in Nondiabetic Patients With Heart Failure and Reduced Ejection Fraction.
Santos-Gallego CG, Vargas-Delgado AP, Requena-Ibanez JA, Garcia-Ropero A, Mancini D, Pinney S, Macaluso F, Sartori S, Roque M, Sabatel-Perez F, Rodriguez-Cordero A, Zafar MU, Fergus I, Atallah-Lajam F, Contreras JP, Varley C, Moreno PR, Abascal VM, Lala A, Tamler R, Sanz J, Fuster V, Badimon JJ; EMPA-TROPISM (ATRU-4) Investigators. Santos-Gallego CG, et al. Among authors: vargas delgado ap. J Am Coll Cardiol. 2021 Jan 26;77(3):243-255. doi: 10.1016/j.jacc.2020.11.008. Epub 2020 Nov 13. J Am Coll Cardiol. 2021. PMID: 33197559 Free article. Clinical Trial.
Mechanistic Insights of Empagliflozin in Nondiabetic Patients With HFrEF: From the EMPA-TROPISM Study.
Requena-Ibáñez JA, Santos-Gallego CG, Rodriguez-Cordero A, Vargas-Delgado AP, Mancini D, Sartori S, Atallah-Lajam F, Giannarelli C, Macaluso F, Lala A, Sanz J, Fuster V, Badimon JJ. Requena-Ibáñez JA, et al. Among authors: vargas delgado ap. JACC Heart Fail. 2021 Aug;9(8):578-589. doi: 10.1016/j.jchf.2021.04.014. JACC Heart Fail. 2021. PMID: 34325888 Free article. Clinical Trial.
Are the antidiabetic SGLT2 inhibitors a cardiovascular treatment?
Vargas Delgado AP, Requena Ibañez JA, Santos-Gallego CG, Badimon JJ. Vargas Delgado AP, et al. Clin Investig Arterioscler. 2020 Oct 21:S0214-9168(20)30083-8. doi: 10.1016/j.arteri.2020.08.001. Online ahead of print. Clin Investig Arterioscler. 2020. PMID: 34756346 Review. English, Spanish.
Empagliflozin Ameliorates Diastolic Dysfunction and Left Ventricular Fibrosis/Stiffness in Nondiabetic Heart Failure: A Multimodality Study.
Santos-Gallego CG, Requena-Ibanez JA, San Antonio R, Garcia-Ropero A, Ishikawa K, Watanabe S, Picatoste B, Vargas-Delgado AP, Flores-Umanzor EJ, Sanz J, Fuster V, Badimon JJ. Santos-Gallego CG, et al. Among authors: vargas delgado ap. JACC Cardiovasc Imaging. 2021 Feb;14(2):393-407. doi: 10.1016/j.jcmg.2020.07.042. Epub 2020 Oct 29. JACC Cardiovasc Imaging. 2021. PMID: 33129742 Free article.
Correlation between myocardial strain and adverse remodeling in a non-diabetic model of heart failure following empagliflozin therapy.
Garcia-Ropero A, Santos-Gallego CG, Vargas-Delgado AP, Requena-Ibanez JA, Picatoste B, Ishikawa K, Sanz J, Tunon J, Badimon JJ. Garcia-Ropero A, et al. Among authors: vargas delgado ap. Expert Rev Cardiovasc Ther. 2020 Sep;18(9):635-642. doi: 10.1080/14779072.2020.1802247. Epub 2020 Aug 9. Expert Rev Cardiovasc Ther. 2020. PMID: 32713221