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Page 1
Diversity, classification and evolution of CRISPR-Cas systems.
Koonin EV, Makarova KS, Zhang F. Koonin EV, et al. Curr Opin Microbiol. 2017 Jun;37:67-78. doi: 10.1016/j.mib.2017.05.008. Epub 2017 Jun 9. Curr Opin Microbiol. 2017. PMID: 28605718 Free PMC article. Review.
The bacterial and archaeal CRISPR-Cas systems of adaptive immunity show remarkable diversity of protein composition, effector complex structure, genome locus architecture and mechanisms of adaptation, pre-CRISPR (cr)RNA processing and interference. ...
The bacterial and archaeal CRISPR-Cas systems of adaptive immunity show remarkable diversity of protein composition, effector complex struct …
Radiomics and artificial intelligence in lung cancer screening.
Binczyk F, Prazuch W, Bozek P, Polanska J. Binczyk F, et al. Transl Lung Cancer Res. 2021 Feb;10(2):1186-1199. doi: 10.21037/tlcr-20-708. Transl Lung Cancer Res. 2021. PMID: 33718055 Free PMC article. Review.
Such an approach involves the design of artificial neural network architecture while upholding the goal of high classification accuracy. ...
Such an approach involves the design of artificial neural network architecture while upholding the goal of high classification accura …
Sleep disorders and exercise: a mini-review.
Shah NM, Bennett C, Hassan H, Kaltsakas G. Shah NM, et al. J Thorac Dis. 2023 Oct 31;15(10):5863-5872. doi: 10.21037/jtd-23-17. Epub 2023 Sep 18. J Thorac Dis. 2023. PMID: 37969282 Free PMC article. Review.
In individuals without sleep disorders, exercise appears to be beneficial in improving sleep architecture without any impact of the timing of exercise in relation to onset of sleep. ...In primary sleep disorders such as insomnia, narcolepsy and restless syndrome exercise m …
In individuals without sleep disorders, exercise appears to be beneficial in improving sleep architecture without any impact of the t …
Cancer epigenetics: promises and pitfalls for cancer therapy.
Skourti E, Dhillon P. Skourti E, et al. FEBS J. 2022 Mar;289(5):1156-1159. doi: 10.1111/febs.16395. FEBS J. 2022. PMID: 35233949 Free article.
The diverse topics explored herein range from the roles of transposable elements and chromatin architecture in cancer and the most recent research advances on cancer-associated histone variants (oncohistones), to the effects of altered epigenetics on transcription and adva …
The diverse topics explored herein range from the roles of transposable elements and chromatin architecture in cancer and the most re …
Tumor heterogeneity in muscle-invasive bladder cancer.
Kang HW, Kim WJ, Choi W, Yun SJ. Kang HW, et al. Transl Androl Urol. 2020 Dec;9(6):2866-2880. doi: 10.21037/tau.2020.03.13. Transl Androl Urol. 2020. PMID: 33457261 Free PMC article. Review.
Genomic characterization of time-series analyses at the single cell level, and of cell-free circulating tumor DNA or circulating tumor cells, are emerging technologies that enable dissection of the complex clonal architecture of MIBC. This review provides insight into the …
Genomic characterization of time-series analyses at the single cell level, and of cell-free circulating tumor DNA or circulating tumor cells …
Narrative review of sleep and stroke.
Pérez-Carbonell L, Bashir S. Pérez-Carbonell L, et al. J Thorac Dis. 2020 Oct;12(Suppl 2):S176-S190. doi: 10.21037/jtd-cus-2020-002. J Thorac Dis. 2020. PMID: 33214922 Free PMC article. Review.
Cardiovascular physiological changes during sleep are described, as well as the evidence on the relationship between stroke and sleep duration, SDB, RLS, insomnia, excessive daytime sleepiness (EDS), and circadian rhythm alterations. Potential changes on sleep architecture …
Cardiovascular physiological changes during sleep are described, as well as the evidence on the relationship between stroke and sleep durati …
Risk stratification for upper tract urinary carcinoma.
Benamran D, Seisen T, Naoum E, Vaessen C, Parra J, Mozer P, Shariat SF, Rouprêt M. Benamran D, et al. Transl Androl Urol. 2020 Aug;9(4):1799-1808. doi: 10.21037/tau.2019.12.21. Transl Androl Urol. 2020. PMID: 32944543 Free PMC article. Review.
Preoperative risk factors can be viewed as patient-related risk factors (gender, age, ethnicity, body mass index, smoking status, or genetic factors), or tumor-related risk factors (stage, grade, size, architecture, multifocality, ureteric obstruction). Several biomarkers, …
Preoperative risk factors can be viewed as patient-related risk factors (gender, age, ethnicity, body mass index, smoking status, or genetic …
In conversation with Carol Robinson.
Dhillon P, Robinson C. Dhillon P, et al. FEBS J. 2023 Sep;290(18):4376-4381. doi: 10.1111/febs.16743. Epub 2023 Mar 9. FEBS J. 2023. PMID: 36892400
In her research, she has also continuously pushed boundaries, pioneering the application of mass spectrometry for the elucidation of the 3D architecture of macromolecular complexes, including membrane-bound assemblies. ...
In her research, she has also continuously pushed boundaries, pioneering the application of mass spectrometry for the elucidation of the 3D …
Diversity and Scale: Genetic Architecture of 2,068 Traits in the VA Million Veteran Program.
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F, Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Sun YV, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao PS, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano MJ, Madduri RK, Damrauer SM, Liao KP. Verma A, et al. medRxiv [Preprint]. 2023 Jun 29:2023.06.28.23291975. doi: 10.1101/2023.06.28.23291975. medRxiv. 2023. PMID: 37425708 Free PMC article. Preprint.
Genome-wide association studies (GWAS) have underrepresented individuals from non-European populations, impeding progress in characterizing the genetic architecture and consequences of health and disease traits. To address this, we present a population-stratified phenome-w …
Genome-wide association studies (GWAS) have underrepresented individuals from non-European populations, impeding progress in characterizing …
36 results