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The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology.
Barnum CE, Al Saai S, Patel SD, Cheng C, Anand D, Xu X, Dash S, Siddam AD, Glazewski L, Paglione E, Polson SW, Chuma S, Mason RW, Wei S, Batish M, Fowler VM, Lachke SA. Barnum CE, et al. Among authors: siddam ad. Hum Mol Genet. 2020 Jul 29;29(12):2076-2097. doi: 10.1093/hmg/ddaa096. Hum Mol Genet. 2020. PMID: 32420594 Free PMC article.
Compound mouse mutants of bZIP transcription factors Mafg and Mafk reveal a regulatory network of non-crystallin genes associated with cataract.
Agrawal SA, Anand D, Siddam AD, Kakrana A, Dash S, Scheiblin DA, Dang CA, Terrell AM, Waters SM, Singh A, Motohashi H, Yamamoto M, Lachke SA. Agrawal SA, et al. Among authors: siddam ad. Hum Genet. 2015 Jul;134(7):717-35. doi: 10.1007/s00439-015-1554-5. Epub 2015 Apr 21. Hum Genet. 2015. PMID: 25896808 Free PMC article.
The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development.
Aryal S, Viet J, Weatherbee BAT, Siddam AD, Hernandez FG, Gautier-Courteille C, Paillard L, Lachke SA. Aryal S, et al. Among authors: siddam ad. Hum Genet. 2020 Dec;139(12):1541-1554. doi: 10.1007/s00439-020-02195-7. Epub 2020 Jun 27. Hum Genet. 2020. PMID: 32594240 Free PMC article.