Design, synthesis and anticancer activity of fluorocyclopentenyl-purines and - pyrimidines.
Yoon JS, Jarhad DB, Kim G, Nayak A, Zhao LX, Yu J, Kim HR, Lee JY, Mulamoottil VA, Chandra G, Byun WS, Lee SK, Kim YC, Jeong LS.
Yoon JS, et al.
Eur J Med Chem. 2018 Jul 15;155:406-417. doi: 10.1016/j.ejmech.2018.06.003. Epub 2018 Jun 5.
Eur J Med Chem. 2018.
PMID: 29906687
Among all the synthesized purine nucleosides, adenine derivative 1b and N(6)-methyladenine derivative 3k showed potent anticancer activity, showing equipotent inhibitory activity as the positive control, neplanocin A (1a) or Ara-C. However, the phosphoramidate prodrug 3p s …
Among all the synthesized purine nucleosides, adenine derivative 1b and N(6)-methyladenine derivative 3k showed potent anticancer activity, …