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The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2.
Krasemann S, Haferkamp U, Pfefferle S, Woo MS, Heinrich F, Schweizer M, Appelt-Menzel A, Cubukova A, Barenberg J, Leu J, Hartmann K, Thies E, Littau JL, Sepulveda-Falla D, Zhang L, Ton K, Liang Y, Matschke J, Ricklefs F, Sauvigny T, Sperhake J, Fitzek A, Gerhartl A, Brachner A, Geiger N, König EM, Bodem J, Franzenburg S, Franke A, Moese S, Müller FJ, Geisslinger G, Claussen C, Kannt A, Zaliani A, Gribbon P, Ondruschka B, Neuhaus W, Friese MA, Glatzel M, Pless O. Krasemann S, et al. Among authors: appelt menzel a. Stem Cell Reports. 2022 Feb 8;17(2):307-320. doi: 10.1016/j.stemcr.2021.12.011. Epub 2022 Jan 20. Stem Cell Reports. 2022. PMID: 35063125 Free PMC article.
Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier.
Holst MR, de Wit NM, Ozgür B, Brachner A, Hyldig K, Appelt-Menzel A, Sleven H, Cader Z, de Vries HE, Neuhaus W, Jensen A, Brodin B, Nielsen MS. Holst MR, et al. Among authors: appelt menzel a. Fluids Barriers CNS. 2023 Nov 6;20(1):82. doi: 10.1186/s12987-023-00480-x. Fluids Barriers CNS. 2023. PMID: 37932749 Free PMC article.
Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line.
Ozgür B, Puris E, Brachner A, Appelt-Menzel A, Oerter S, Balzer V, Holst MR, Christiansen RF, Hyldig K, Buckley ST, Kristensen M, Auriola S, Jensen A, Fricker G, Nielsen MS, Neuhaus W, Brodin B. Ozgür B, et al. Among authors: appelt menzel a. Fluids Barriers CNS. 2023 Dec 19;20(1):96. doi: 10.1186/s12987-023-00501-9. Fluids Barriers CNS. 2023. PMID: 38115090 Free PMC article.
Overcoming the blood-brain barrier? - prediction of blood-brain permeability of hydrophobically modified polyethylenimine polyplexes for siRNA delivery into the brain with in vitro and in vivo models.
Hartl N, Gabold B, Adams F, Uhl P, Oerter S, Gätzner S, Metzger M, König AC, Hauck SM, Appelt-Menzel A, Mier W, Fricker G, Merkel OM. Hartl N, et al. Among authors: appelt menzel a. J Control Release. 2023 Aug;360:613-629. doi: 10.1016/j.jconrel.2023.07.019. Epub 2023 Jul 15. J Control Release. 2023. PMID: 37437848
Human isogenic cells of the neurovascular unit exert transcriptomic cell type-specific effects on a blood-brain barrier in vitro model of late-onset Alzheimer disease.
Haferkamp U, Hartmann C, Abid CL, Brachner A, Höchner A, Gerhartl A, Harwardt B, Leckzik S, Leu J, Metzger M, Nastainczyk-Wulf M, Neuhaus W, Oerter S, Pless O, Rujescu D, Jung M, Appelt-Menzel A. Haferkamp U, et al. Among authors: appelt menzel a. Fluids Barriers CNS. 2023 Oct 31;20(1):78. doi: 10.1186/s12987-023-00471-y. Fluids Barriers CNS. 2023. PMID: 37907966 Free PMC article.
20 results