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1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors.
Mulvihill MJ, Ji QS, Werner D, Beck P, Cesario C, Cooke A, Cox M, Crew A, Dong H, Feng L, Foreman KW, Mak G, Nigro A, O'Connor M, Saroglou L, Stolz KM, Sujka I, Volk B, Weng Q, Wilkes R. Mulvihill MJ, et al. Among authors: nigro a. Bioorg Med Chem Lett. 2007 Feb 15;17(4):1091-7. doi: 10.1016/j.bmcl.2006.11.016. Epub 2006 Nov 10. Bioorg Med Chem Lett. 2007. PMID: 17127062
Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors.
Mulvihill MJ, Ji QS, Coate HR, Cooke A, Dong H, Feng L, Foreman K, Rosenfeld-Franklin M, Honda A, Mak G, Mulvihill KM, Nigro AI, O'Connor M, Pirrit C, Steinig AG, Siu K, Stolz KM, Sun Y, Tavares PA, Yao Y, Gibson NW. Mulvihill MJ, et al. Among authors: nigro ai. Bioorg Med Chem. 2008 Feb 1;16(3):1359-75. doi: 10.1016/j.bmc.2007.10.061. Epub 2007 Oct 23. Bioorg Med Chem. 2008. PMID: 17983756
3-[6-(2-Dimethylamino-1-imidazol-1-yl-butyl)-naphthalen-2-yloxy]-2,2-dimethyl-propionic acid as a highly potent and selective retinoic acid metabolic blocking agent.
Mulvihill MJ, Kan JL, Cooke A, Bhagwat S, Beck P, Bittner M, Cesario C, Keane D, Lazarescu V, Nigro A, Nillson C, Panicker B, Smith V, Srebernak M, Sun FL, O'Connor M, Russo S, Fischetti G, Vrkljan M, Winski S, Castelhano AL, Emerson D, Gibson NW. Mulvihill MJ, et al. Among authors: nigro a. Bioorg Med Chem Lett. 2006 May 15;16(10):2729-33. doi: 10.1016/j.bmcl.2006.02.020. Epub 2006 Feb 28. Bioorg Med Chem Lett. 2006. PMID: 16504501
Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs).
Mulvihill MJ, Kan JL, Beck P, Bittner M, Cesario C, Cooke A, Keane DM, Nigro AI, Nillson C, Smith V, Srebernak M, Sun FL, Vrkljan M, Winski SL, Castelhano AL, Emerson D, Gibson N. Mulvihill MJ, et al. Among authors: nigro ai. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1669-73. doi: 10.1016/j.bmcl.2005.01.044. Bioorg Med Chem Lett. 2005. PMID: 15745819