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Page 1
Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei.
Alghamdi AH, Munday JC, Campagnaro GD, Gurvic D, Svensson F, Okpara CE, Kumar A, Quintana J, Martin Abril ME, Milić P, Watson L, Paape D, Settimo L, Dimitriou A, Wielinska J, Smart G, Anderson LF, Woodley CM, Kelly SPY, Ibrahim HM, Hulpia F, Al-Salabi MI, Eze AA, Sprenger T, Teka IA, Gudin S, Weyand S, Field M, Dardonville C, Tidwell RR, Carrington M, O'Neill P, Boykin DW, Zachariae U, De Koning HP. Alghamdi AH, et al. Among authors: eze aa. Elife. 2020 Aug 11;9:e56416. doi: 10.7554/eLife.56416. Elife. 2020. PMID: 32762841 Free PMC article.
Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake.
Munday JC, Rojas López KE, Eze AA, Delespaux V, Van Den Abbeele J, Rowan T, Barrett MP, Morrison LJ, de Koning HP. Munday JC, et al. Among authors: eze aa. Int J Parasitol Drugs Drug Resist. 2013 Feb 10;3:69-76. doi: 10.1016/j.ijpddr.2013.01.004. eCollection 2013 Dec. Int J Parasitol Drugs Drug Resist. 2013. PMID: 24533295 Free PMC article.
The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes.
Teka IA, Kazibwe AJ, El-Sabbagh N, Al-Salabi MI, Ward CP, Eze AA, Munday JC, Mäser P, Matovu E, Barrett MP, de Koning HP. Teka IA, et al. Among authors: eze aa. Mol Pharmacol. 2011 Jul;80(1):110-6. doi: 10.1124/mol.111.071555. Epub 2011 Mar 24. Mol Pharmacol. 2011. PMID: 21436312 Free PMC article.
20 results