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Page 1
Inferring pulmonary exposure based on clinical PK data: accuracy and precision of model-based deconvolution methods.
J Pharmacokinet Pharmacodyn. 2022 Apr;49(2):135-149. doi: 10.1007/s10928-021-09780-x. Epub 2021 Sep 28.
J Pharmacokinet Pharmacodyn. 2022.
PMID: 34585333
Free PMC article.
Understanding the suitability of established antibiotics for oral inhalation from a pharmacokinetic perspective: an integrated model-based investigation based on rifampicin, ciprofloxacin and tigecycline in vivo data.
Himstedt A, Braun C, Wicha SG, Borghardt JM.
Himstedt A, et al.
J Antimicrob Chemother. 2022 Oct 28;77(11):2922-2932. doi: 10.1093/jac/dkac240.
J Antimicrob Chemother. 2022.
PMID: 35904005
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Integration of physiological changes during the postpartum period into a PBPK framework and prediction of amoxicillin disposition before and shortly after delivery.
Dallmann A, Himstedt A, Solodenko J, Ince I, Hempel G, Eissing T.
Dallmann A, et al. Among authors: himstedt a.
J Pharmacokinet Pharmacodyn. 2020 Aug;47(4):341-359. doi: 10.1007/s10928-020-09706-z. Epub 2020 Aug 3.
J Pharmacokinet Pharmacodyn. 2020.
PMID: 32748112
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Towards a Quantitative Mechanistic Understanding of Localized Pulmonary Tissue Retention-A Combined In Vivo/In Silico Approach Based on Four Model Drugs.
Himstedt A, Braun C, Wicha SG, Borghardt JM.
Himstedt A, et al.
Pharmaceutics. 2020 Apr 29;12(5):408. doi: 10.3390/pharmaceutics12050408.
Pharmaceutics. 2020.
PMID: 32365674
Free PMC article.
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Muscle to Brain Partitioning as Measure of Transporter-Mediated Efflux at the Rat Blood-Brain Barrier and Its Implementation into Compound Optimization in Drug Discovery.
Cui Y, Lotz R, Rapp H, Klinder K, Himstedt A, Sauer A.
Cui Y, et al. Among authors: himstedt a.
Pharmaceutics. 2019 Nov 11;11(11):595. doi: 10.3390/pharmaceutics11110595.
Pharmaceutics. 2019.
PMID: 31718023
Free PMC article.
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