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The lauric acid-activated signaling prompts apoptosis in cancer cells.
Lappano R, Sebastiani A, Cirillo F, Rigiracciolo DC, Galli GR, Curcio R, Malaguarnera R, Belfiore A, Cappello AR, Maggiolini M. Lappano R, et al. Among authors: sebastiani a. Cell Death Discov. 2017 Sep 18;3:17063. doi: 10.1038/cddiscovery.2017.63. eCollection 2017. Cell Death Discov. 2017. PMID: 28924490 Free PMC article.
GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer.
Cirillo F, Pellegrino M, Malivindi R, Rago V, Avino S, Muto L, Dolce V, Vivacqua A, Rigiracciolo DC, De Marco P, Sebastiani A, Abonante S, Nakajima M, Lappano R, Maggiolini M. Cirillo F, et al. Among authors: sebastiani a. Oncotarget. 2017 Nov 20;8(63):106608-106624. doi: 10.18632/oncotarget.22541. eCollection 2017 Dec 5. Oncotarget. 2017. PMID: 29290975 Free PMC article.
miR-221 stimulates breast cancer cells and cancer-associated fibroblasts (CAFs) through selective interference with the A20/c-Rel/CTGF signaling.
Santolla MF, Lappano R, Cirillo F, Rigiracciolo DC, Sebastiani A, Abonante S, Tassone P, Tagliaferri P, Di Martino MT, Maggiolini M, Vivacqua A. Santolla MF, et al. Among authors: sebastiani a. J Exp Clin Cancer Res. 2018 May 2;37(1):94. doi: 10.1186/s13046-018-0767-6. J Exp Clin Cancer Res. 2018. PMID: 29716623 Free PMC article.