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Dengue virus NS1 secretion is regulated via importin-subunit β1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin.
Denolly S, Guo H, Martens M, Płaszczyca A, Scaturro P, Prasad V, Kongmanas K, Punyadee N, Songjaeng A, Mairiang D, Pichlmair A, Avirutnan P, Bartenschlager R. Denolly S, et al. Among authors: plaszczyca a. mBio. 2023 Oct 31;14(5):e0144123. doi: 10.1128/mbio.01441-23. Epub 2023 Sep 13. mBio. 2023. PMID: 37702492 Free PMC article.
Prevalence of SARS-CoV-2 Infection in Children and Their Parents in Southwest Germany.
Tönshoff B, Müller B, Elling R, Renk H, Meissner P, Hengel H, Garbade SF, Kieser M, Jeltsch K, Grulich-Henn J, Euler J, Stich M, Chobanyan-Jürgens K, Zernickel M, Janda A, Wölfle L, Stamminger T, Iftner T, Ganzenmueller T, Schmitt C, Görne T, Laketa V, Olberg S, Plaszczyca A, Cortese M, Bartenschlager R, Pape C, Remme R, Huzly D, Panning M, Weigang S, Giese S, Ciminski K, Ankerhold J, Kochs G, Schwemmle M, Handgretinger R, Niemeyer CM, Engel C, Kern WV, Hoffmann GF, Franz AR, Henneke P, Debatin KM, Kräusslich HG. Tönshoff B, et al. Among authors: plaszczyca a. JAMA Pediatr. 2021 Jun 1;175(6):586-593. doi: 10.1001/jamapediatrics.2021.0001. JAMA Pediatr. 2021. PMID: 33480966 Free PMC article.
An orthogonal proteomic survey uncovers novel Zika virus host factors.
Scaturro P, Stukalov A, Haas DA, Cortese M, Draganova K, Płaszczyca A, Bartenschlager R, Götz M, Pichlmair A. Scaturro P, et al. Among authors: plaszczyca a. Nature. 2018 Sep;561(7722):253-257. doi: 10.1038/s41586-018-0484-5. Epub 2018 Sep 3. Nature. 2018. PMID: 30177828
A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle.
Płaszczyca A, Scaturro P, Neufeldt CJ, Cortese M, Cerikan B, Ferla S, Brancale A, Pichlmair A, Bartenschlager R. Płaszczyca A, et al. PLoS Pathog. 2019 May 9;15(5):e1007736. doi: 10.1371/journal.ppat.1007736. eCollection 2019 May. PLoS Pathog. 2019. PMID: 31071189 Free PMC article.
A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial.
Janssen M, Schäkel U, Djuka Fokou C, Krisam J, Stermann J, Kriegsmann K, Haberbosch I, Novotny JP, Weber S, Vehreschild M, Bornhäuser M, Bullinger L, Schmitt M, Liebregts T, Dreger P, Lorenz HM, Plaszczyca A, Bartenschlager R, Müller B, Kräusslich HG, Halama N, Jäger D, Schlenk RF, Leo A, Meuer S, Weigand MA, Motsch J, Merle U, Denkinger CM, Müller-Tidow C. Janssen M, et al. Among authors: plaszczyca a. Trials. 2020 Oct 6;21(1):828. doi: 10.1186/s13063-020-04735-y. Trials. 2020. PMID: 33023671 Free PMC article.