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RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia.
Lipka DB, Witte T, Toth R, Yang J, Wiesenfarth M, Nöllke P, Fischer A, Brocks D, Gu Z, Park J, Strahm B, Wlodarski M, Yoshimi A, Claus R, Lübbert M, Busch H, Boerries M, Hartmann M, Schönung M, Kilik U, Langstein J, Wierzbinska JA, Pabst C, Garg S, Catalá A, De Moerloose B, Dworzak M, Hasle H, Locatelli F, Masetti R, Schmugge M, Smith O, Stary J, Ussowicz M, van den Heuvel-Eibrink MM, Assenov Y, Schlesner M, Niemeyer C, Flotho C, Plass C. Lipka DB, et al. Nat Commun. 2017 Dec 19;8(1):2126. doi: 10.1038/s41467-017-02177-w. Nat Commun. 2017. PMID: 29259247 Free PMC article. Clinical Trial.
RASA4 undergoes DNA hypermethylation in resistant juvenile myelomonocytic leukemia.
Poetsch AR, Lipka DB, Witte T, Claus R, Nöllke P, Zucknick M, Olk-Batz C, Fluhr S, Dworzak M, De Moerloose B, Starý J, Zecca M, Hasle H, Schmugge M, van den Heuvel-Eibrink MM, Locatelli F, Niemeyer CM, Flotho C, Plass C. Poetsch AR, et al. Epigenetics. 2014 Sep;9(9):1252-60. doi: 10.4161/epi.29941. Epub 2014 Jul 31. Epigenetics. 2014. PMID: 25147919 Free PMC article.