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Flagellin-fused protein targeting M2e and HA2 induces potent humoral and T-cell responses and protects mice against various influenza viruses a subtypes.
Stepanova LA, Mardanova ES, Shuklina MA, Blokhina EA, Kotlyarov RY, Potapchuk MV, Kovaleva AA, Vidyaeva IG, Korotkov AV, Eletskaya EI, Ravin NV, Tsybalova LM. Stepanova LA, et al. Among authors: kovaleva aa. J Biomed Sci. 2018 Apr 9;25(1):33. doi: 10.1186/s12929-018-0433-5. J Biomed Sci. 2018. PMID: 29631629 Free PMC article.
Development of a candidate influenza vaccine based on virus-like particles displaying influenza M2e peptide into the immunodominant loop region of hepatitis B core antigen: Insertion of multiple copies of M2e increases immunogenicity and protective efficiency.
Ravin NV, Blokhina EA, Kuprianov VV, Stepanova LA, Shaldjan AA, Kovaleva AA, Tsybalova LM, Skryabin KG. Ravin NV, et al. Among authors: kovaleva aa. Vaccine. 2015 Jun 26;33(29):3392-7. doi: 10.1016/j.vaccine.2015.04.066. Epub 2015 Apr 29. Vaccine. 2015. PMID: 25937448
Protection against multiple influenza A virus strains induced by candidate recombinant vaccine based on heterologous M2e peptides linked to flagellin.
Stepanova LA, Kotlyarov RY, Kovaleva AA, Potapchuk MV, Korotkov AV, Sergeeva MV, Kasianenko MA, Kuprianov VV, Ravin NV, Tsybalova LM, Skryabin KG, Kiselev OI. Stepanova LA, et al. Among authors: kovaleva aa. PLoS One. 2015 Mar 23;10(3):e0119520. doi: 10.1371/journal.pone.0119520. eCollection 2015. PLoS One. 2015. PMID: 25799221 Free PMC article.