Abstract
A reaction of bis[(2-chlorocarbonyl)phenyl] diselenide with various mono and bisnucleophiles such as aminophenols, phenols, and amines have been studied as a convenient general route to a series of new antimicrobial and antiviral diphenyl diselenides. The compounds, particularly bis[2-(hydroxyphenylcarbamoyl)]phenyl diselenides and reference benzisoselenazol-3(2H)-ones, exhibited high antimicrobial activity against Gram-positive bacterial species (Enterococcus spp., Staphylococcus spp.), and some compounds were also active against Gram-negative E. coli and fungi (Candida spp., A.niger). The majority of compounds demonstrated high activity against human herpes virus type 1 (HHV-1) and moderate activity against encephalomyocarditis virus (EMCV), while they were generally inactive against vesicular stomatitis virus (VSV).
Keywords:
2-hydroxyacetanilide; antimicrobial activity; antimycin A; antiviral activity; benzisoselenazol-3(2H)-ones; benzohydrazide; diselenides; ebselen; morpholine; organoselenium compounds.
MeSH terms
-
Amines / chemical synthesis
-
Amines / chemistry
-
Aminophenols / chemical synthesis
-
Aminophenols / chemistry
-
Anti-Infective Agents / chemical synthesis
-
Anti-Infective Agents / chemistry
-
Anti-Infective Agents / pharmacology*
-
Antifungal Agents / chemical synthesis
-
Antifungal Agents / chemistry
-
Antifungal Agents / pharmacology*
-
Antioxidants / chemical synthesis
-
Antioxidants / chemistry
-
Antiviral Agents / chemical synthesis
-
Antiviral Agents / chemistry
-
Antiviral Agents / pharmacology*
-
Benzene Derivatives / chemical synthesis
-
Benzene Derivatives / chemistry
-
Benzene Derivatives / pharmacology*
-
Candida / drug effects
-
Candida / pathogenicity
-
Escherichia coli / drug effects
-
Escherichia coli / pathogenicity
-
Herpesvirus 1, Human / drug effects
-
Herpesvirus 1, Human / pathogenicity
-
Humans
-
Microbial Sensitivity Tests
-
Organoselenium Compounds / chemical synthesis
-
Organoselenium Compounds / chemistry
-
Organoselenium Compounds / pharmacology*
-
Phenols / chemical synthesis
-
Phenols / chemistry
Substances
-
Amines
-
Aminophenols
-
Anti-Infective Agents
-
Antifungal Agents
-
Antioxidants
-
Antiviral Agents
-
Benzene Derivatives
-
Organoselenium Compounds
-
Phenols
-
diphenyldiselenide