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NF1 mutations are recurrent in adult acute myeloid leukemia and confer poor outcome.
Leukemia. 2018 Dec;32(12):2536-2545. doi: 10.1038/s41375-018-0147-4. Epub 2018 Jun 5.
Leukemia. 2018.
PMID: 29872168
Free PMC article.
NF1-mutated patients belonged more often to the adverse European LeukemiaNet (ELN) risk category than NF1 wild-type patients. Among patients aged <60 years, the presence of NF1 Thr676 mutations was associated with lower complete remission (CR) rates (P = 0.04) and short …
NF1-mutated patients belonged more often to the adverse European LeukemiaNet (ELN) risk category than NF1 wild-type patients. Among p …
Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine.
Pagel R, Bär F, Schröder T, Sünderhauf A, Künstner A, Ibrahim SM, Autenrieth SE, Kalies K, König P, Tsang AH, Bettenworth D, Divanovic S, Lehnert H, Fellermann K, Oster H, Derer S, Sina C.
Pagel R, et al.
FASEB J. 2017 Nov;31(11):4707-4719. doi: 10.1096/fj.201700141RR. Epub 2017 Jul 14.
FASEB J. 2017.
PMID: 28710114
Free PMC article.
However, the underlying molecular mechanisms remain unknown. Intestinal biopsies from Per1/2 mutant and wild-type (WT) mice were investigated by electron microscopy, immunohistochemistry, and bromodeoxyuridine pulse-chase experiments. ...
However, the underlying molecular mechanisms remain unknown. Intestinal biopsies from Per1/2 mutant and wild-type (WT) mice were inve …
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