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Patched knockout mouse models of Basal cell carcinoma.
Nitzki F, Becker M, Frommhold A, Schulz-Schaeffer W, Hahn H. Nitzki F, et al. Among authors: frommhold a. J Skin Cancer. 2012;2012:907543. doi: 10.1155/2012/907543. Epub 2012 Sep 13. J Skin Cancer. 2012. PMID: 23024864 Free PMC article.
The Hedgehog receptor Patched controls lymphoid lineage commitment.
Uhmann A, Dittmann K, Nitzki F, Dressel R, Koleva M, Frommhold A, Zibat A, Binder C, Adham I, Nitsche M, Heller T, Armstrong V, Schulz-Schaeffer W, Wienands J, Hahn H. Uhmann A, et al. Among authors: frommhold a. Blood. 2007 Sep 15;110(6):1814-23. doi: 10.1182/blood-2007-02-075648. Epub 2007 May 29. Blood. 2007. PMID: 17536012 Free article.
Tumor stroma-derived Wnt5a induces differentiation of basal cell carcinoma of Ptch-mutant mice via CaMKII.
Nitzki F, Zibat A, König S, Wijgerde M, Rosenberger A, Brembeck FH, Carstens PO, Frommhold A, Uhmann A, Klingler S, Reifenberger J, Pukrop T, Aberger F, Schulz-Schaeffer W, Hahn H. Nitzki F, et al. Among authors: frommhold a. Cancer Res. 2010 Apr 1;70(7):2739-48. doi: 10.1158/0008-5472.CAN-09-3743. Epub 2010 Mar 16. Cancer Res. 2010. PMID: 20233865
DMBA/TPA treatment is necessary for BCC formation from patched deficient epidermal cells in Ptch(flox/flox)CD4Cre(+/-) mice.
Uhmann A, Heß I, Frommhold A, König S, Zabel S, Nitzki F, Dittmann K, Lühder F, Christiansen H, Reifenberger J, Schulz-Schaeffer W, Hahn H. Uhmann A, et al. Among authors: frommhold a. J Invest Dermatol. 2014 Oct;134(10):2620-2629. doi: 10.1038/jid.2014.157. Epub 2014 Mar 24. J Invest Dermatol. 2014. PMID: 24662765 Free article.