Zebrafish neurobehavioral phenomics for aquatic neuropharmacology and toxicology research

Allan V Kalueff; David J Echevarria; Sumit Homechaudhuri; Adam Michael Stewart; Adam D Collier; Aleksandra A Kaluyeva; Shaomin Li; Yingcong Liu; Peirong Chen; JiaJia Wang; Lei Yang; Anisa Mitra; Subharthi Pal; Adwitiya Chaudhuri; Anwesha Roy; Missidona Biswas; Dola Roy; Anupam Podder; Manoj K Poudel; Deepshikha P Katare; Ruchi J Mani; Evan J Kyzar; Siddharth Gaikwad; Michael Nguyen; Cai Song; International Zebrafish Neuroscience Research Consortium ZNRC

doi:10.1016/j.aquatox.2015.08.007

Zebrafish neurobehavioral phenomics for aquatic neuropharmacology and toxicology research

Aquat Toxicol. 2016 Jan:170:297-309. doi: 10.1016/j.aquatox.2015.08.007. Epub 2015 Aug 24.

Authors

Allan V Kalueff¹, David J Echevarria², Sumit Homechaudhuri³, Adam Michael Stewart⁴, Adam D Collier², Aleksandra A Kaluyeva⁵, Shaomin Li⁶, Yingcong Liu⁶, Peirong Chen⁶, JiaJia Wang⁶, Lei Yang⁶, Anisa Mitra³, Subharthi Pal³, Adwitiya Chaudhuri³, Anwesha Roy³, Missidona Biswas³, Dola Roy³, Anupam Podder³, Manoj K Poudel⁴, Deepshikha P Katare⁷, Ruchi J Mani⁷, Evan J Kyzar⁸, Siddharth Gaikwad⁹, Michael Nguyen⁴, Cai Song¹⁰; International Zebrafish Neuroscience Research Consortium ZNRC

Affiliations

¹ Research Institute for Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong 524025, China; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA 70458, USA; ZENEREI Institute, 309 Palmer Court, Slidell, LA 70458, USA; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg 199034, Russia; Chemical-Technological Institute and Institute of Natural Sciences, Ural Federal University, Ekaterinburg 620002, Russia. Electronic address: avkalueff@gmail.com.
² The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA 70458, USA; Department of Psychology, University of Southern Mississippi, 118 College Drive, Hattiesburg, MS 39406, USA.
³ Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, India.
⁴ The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA 70458, USA; ZENEREI Institute, 309 Palmer Court, Slidell, LA 70458, USA.
⁵ ZENEREI Institute, 309 Palmer Court, Slidell, LA 70458, USA.
⁶ Research Institute for Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong 524025, China.
⁷ Proteomics and Translational Research Lab, Centre for Medical Biotechnology, Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida 201303, UP, India.
⁸ The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA 70458, USA; Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, 1601 W Taylor St., Chicago, IL 60612, USA.
⁹ Graduate Institute of Neural and Cognitive Sciences, China Medical University Hospital, Taichung 40402, Taiwan.
¹⁰ Research Institute for Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong 524025, China; Graduate Institute of Neural and Cognitive Sciences, China Medical University Hospital, Taichung 40402, Taiwan.

PMID: 26372090
DOI: 10.1016/j.aquatox.2015.08.007

Abstract

Zebrafish (Danio rerio) are rapidly emerging as an important model organism for aquatic neuropharmacology and toxicology research. The behavioral/phenotypic complexity of zebrafish allows for thorough dissection of complex human brain disorders and drug-evoked pathological states. As numerous zebrafish models become available with a wide spectrum of behavioral, genetic, and environmental methods to test novel drugs, here we discuss recent zebrafish phenomics methods to facilitate drug discovery, particularly in the field of biological psychiatry. Additionally, behavioral, neurological, and endocrine endpoints are becoming increasingly well-characterized in zebrafish, making them an inexpensive, robust and effective model for toxicology research and pharmacological screening. We also discuss zebrafish behavioral phenotypes, experimental considerations, pharmacological candidates and relevance of zebrafish neurophenomics to other 'omics' (e.g., genomic, proteomic) approaches. Finally, we critically evaluate the limitations of utilizing this model organism, and outline future strategies of research in the field of zebrafish phenomics.

Keywords: Aquatic model; Behavior; Ecotoxicology; Neurophenomics; Neuropsychopharmacology; Zebrafish.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Behavior, Animal / drug effects
Humans
Models, Animal
Neurons / drug effects
Neurons / metabolism*
Proteomics*
Psychotropic Drugs / toxicity
Toxicity Tests
Water Pollutants, Chemical / toxicity
Zebrafish / physiology*

Substances

Psychotropic Drugs
Water Pollutants, Chemical