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Year Number of Results
2012 4
2013 1
2014 4
2015 2
2017 2
2018 3
2019 3
2020 1
2021 2
2022 2
2024 0

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Page 1
Therapeutic Strategies to Activate p53.
Aguilar A, Wang S. Aguilar A, et al. Pharmaceuticals (Basel). 2022 Dec 24;16(1):24. doi: 10.3390/ph16010024. Pharmaceuticals (Basel). 2022. PMID: 36678521 Free PMC article. Review.
A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.
Aguilar A, Zhou H, Chen J, Liu L, Bai L, McEachern D, Yang CY, Meagher J, Stuckey J, Wang S. Aguilar A, et al. J Med Chem. 2013 Apr 11;56(7):3048-3067. doi: 10.1021/jm4001105. Epub 2013 Mar 22. J Med Chem. 2013. PMID: 23448298 Free PMC article.
Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.
Xu S, Aguilar A, Xu T, Zheng K, Huang L, Stuckey J, Chinnaswamy K, Bernard D, Fernández-Salas E, Liu L, Wang M, McEachern D, Przybranowski S, Foster C, Wang S. Xu S, et al. Among authors: aguilar a. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1601-1605. doi: 10.1002/anie.201711828. Epub 2018 Jan 15. Angew Chem Int Ed Engl. 2018. PMID: 29284071 Free article.
Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor.
Zhao Y, Zhou B, Bai L, Liu L, Yang CY, Meagher JL, Stuckey JA, McEachern D, Przybranowski S, Wang M, Ran X, Aguilar A, Hu Y, Kampf JW, Li X, Zhao T, Li S, Wen B, Sun D, Wang S. Zhao Y, et al. Among authors: aguilar a. J Med Chem. 2018 Jul 26;61(14):6110-6120. doi: 10.1021/acs.jmedchem.8b00483. Epub 2018 Jul 17. J Med Chem. 2018. PMID: 30015487 Free PMC article.
Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression.
Zhang M, Aguilar A, Xu S, Huang L, Chinnaswamy K, Sleger T, Wang B, Gross S, Nicolay BN, Ronseaux S, Harvey K, Wang Y, McEachern D, Kirchhoff PD, Liu Z, Stuckey J, Tron AE, Liu T, Wang S. Zhang M, et al. Among authors: aguilar a. J Med Chem. 2021 Jul 22;64(14):10333-10349. doi: 10.1021/acs.jmedchem.1c00789. Epub 2021 Jul 1. J Med Chem. 2021. PMID: 34196551 Free PMC article.
Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong In Vivo Antitumor Activity.
Xu S, Aguilar A, Huang L, Xu T, Zheng K, McEachern D, Przybranowski S, Foster C, Zawacki K, Liu Z, Chinnaswamy K, Stuckey J, Wang S. Xu S, et al. Among authors: aguilar a. J Med Chem. 2020 May 14;63(9):4997-5010. doi: 10.1021/acs.jmedchem.0c00547. Epub 2020 Apr 27. J Med Chem. 2020. PMID: 32338903 Free PMC article.
22 results