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Page 1
Showing results for andy blocks
Your search for Andy Bocks retrieved no results
Brain capillary pericytes exert a substantial but slow influence on blood flow.
Hartmann DA, Berthiaume AA, Grant RI, Harrill SA, Koski T, Tieu T, McDowell KP, Faino AV, Kelly AL, Shih AY. Hartmann DA, et al. Nat Neurosci. 2021 May;24(5):633-645. doi: 10.1038/s41593-020-00793-2. Epub 2021 Feb 18. Nat Neurosci. 2021. PMID: 33603231 Free PMC article.
This slow vasoconstriction was inhibited by the clinically used vasodilator fasudil, a Rho-kinase inhibitor that blocks contractile machinery. Capillary pericytes were also slower to constrict back to baseline following hypercapnia-induced dilation, and slower to dilate to …
This slow vasoconstriction was inhibited by the clinically used vasodilator fasudil, a Rho-kinase inhibitor that blocks contractile m …
Ultrasound-guided interscalene blocks.
Gorlin A, Warren L. Gorlin A, et al. J Ultrasound Med. 2012 Jul;31(7):979-83. doi: 10.7863/jum.2012.31.7.979. J Ultrasound Med. 2012. PMID: 22733845 No abstract available.
vCCL2/vMIP-II, the viral master KEYmokine.
Szpakowska M, Chevigné A. Szpakowska M, et al. J Leukoc Biol. 2016 Jun;99(6):893-900. doi: 10.1189/jlb.2MR0815-383R. Epub 2015 Dec 23. J Leukoc Biol. 2016. PMID: 26701133 Review.
Viral CC motif chemokine 2 binds to a broad spectrum of viral and human chemokine receptors of all 4 classes and, depending on the receptor, acts either as an agonist or an antagonist, inducing or blocking the recruitment of specific immune cell subsets. These atypical bin …
Viral CC motif chemokine 2 binds to a broad spectrum of viral and human chemokine receptors of all 4 classes and, depending on the receptor, …
Genomics and epigenetics of sexual commitment in Plasmodium.
Bechtsi DP, Waters AP. Bechtsi DP, et al. Int J Parasitol. 2017 Jun;47(7):425-434. doi: 10.1016/j.ijpara.2017.03.002. Epub 2017 Apr 26. Int J Parasitol. 2017. PMID: 28455236 Free article. Review.
Malaria is the disease caused by the apicomplexan parasites belonging to the genus Plasmodium. Expanding our arsenal to include transmission-blocking agents in our fight against malaria is becoming increasingly important. ...Further insight into sexual commitment and gamet …
Malaria is the disease caused by the apicomplexan parasites belonging to the genus Plasmodium. Expanding our arsenal to include transmission …
A deconstruction-reconstruction strategy for pyrimidine diversification.
Uhlenbruck BJH, Josephitis CM, de Lescure L, Paton RS, McNally A. Uhlenbruck BJH, et al. Nature. 2024 May 2. doi: 10.1038/s41586-024-07474-1. Online ahead of print. Nature. 2024. PMID: 38697196
Transforming pyrmidines into their corresponding N-arylpyrimidinium salts enables cleavage into a three-carbon iminoenamine building block, used for various heterocycle-forming reactions. This deconstruction-reconstruction sequence diversifies the initial pyrimidine core a …
Transforming pyrmidines into their corresponding N-arylpyrimidinium salts enables cleavage into a three-carbon iminoenamine building bloc
Neuropathic pain: emerging treatments.
Dray A. Dray A. Br J Anaesth. 2008 Jul;101(1):48-58. doi: 10.1093/bja/aen107. Epub 2008 May 28. Br J Anaesth. 2008. PMID: 18511441 Free article. Review.
Among the molecular drivers are ion channels (Nav1.7, Nav1.8, Nav1.3, Cav2.2, and alpha2-delta subunits) whose expression is changed during neuropathic pain and their block shows therapeutic utility. Block of a number of ligand-gated channels [transient receptor pot …
Among the molecular drivers are ion channels (Nav1.7, Nav1.8, Nav1.3, Cav2.2, and alpha2-delta subunits) whose expression is changed during …
Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation.
Aggarwal G, Banerjee S, Jones SA, Benchaar Y, Bélanger J, Sévigny M, Smith DM, Niehoff ML, Pavlack M, de Vera IMS, Petkau TL, Leavitt BR, Ling K, Jafar-Nejad P, Rigo F, Morley JE, Farr SA, Dutchak PA, Sephton CF, Nguyen AD. Aggarwal G, et al. J Biol Chem. 2023 Dec;299(12):105475. doi: 10.1016/j.jbc.2023.105475. Epub 2023 Nov 18. J Biol Chem. 2023. PMID: 37981208 Free PMC article.
Here, we tested the efficacy of ASOs as enhancers of progranulin expression by sterically blocking the miR-29b binding site in the 3' UTR of the human GRN mRNA. ...Together, our results demonstrate that ASOs can be used to effectively increase target protein levels by part …
Here, we tested the efficacy of ASOs as enhancers of progranulin expression by sterically blocking the miR-29b binding site in the 3' …
Pharmacology of chronic pain.
Dray A, Urban L, Dickenson A. Dray A, et al. Trends Pharmacol Sci. 1994 Jun;15(6):190-7. doi: 10.1016/0165-6147(94)90147-3. Trends Pharmacol Sci. 1994. PMID: 8091514 Review.
The resultant increase in neural excitability can be reduced with receptor-selective drugs that block peripheral or central chemical mediators or that control ectopic activity or cellular phenotype changes. In this article, Andy Dray, Laszlo Urban and Anthony Dicken …
The resultant increase in neural excitability can be reduced with receptor-selective drugs that block peripheral or central chemical …
39 results