A Randomized Trial Comparing Short versus Prolonged Hemostasis with Rescue Recanalization by Ipsilateral Ulnar Artery Compression: Impact on Radial Artery Occlusion-The RESCUE-RAO Trial

J Interv Cardiol. 2020 Oct 23:2020:7928961. doi: 10.1155/2020/7928961. eCollection 2020.

Abstract

Background: Despite the enormous benefits of radial access, this route is associated with a risk of radial artery occlusion (RAO).

Objective: We compared the incidence of RAO in patients undergoing transradial coronary angiography and intervention after short versus prolonged hemostasis protocol. Also we assessed the efficacy of rescue 1-hour ipsilateral ulnar artery compression if RAO was observed after hemostasis. Material and Methods. Patients referred for elective transradial coronary procedures were eligible. After 6 F radial sheath removal, patients were randomized to short (3 hours) (n = 495) or prolonged (8 hours) (n = 503) hemostasis and a simple bandage was placed over the puncture site. After hemostasis was completed, oximetry plethysmography was used to assess the patency of the radial artery.

Results: One thousand patients were randomized. Baseline characteristics were similar between both groups with average age 61.4 ± 9.4 years (71% male) and PCI performed on half of the patients. The RAO rate immediately after hemostasis was 3.2% in the short hemostasis group and 10.1% in the prolonged group (p < 0.001). Rescue recanalization was successful only in the short group in 56.2% (11/19); at hospital discharge, RAO rates were 1.4% in the short group and 10.1% in the prolonged group (p < 0.001).

Conclusion: Shorter hemostasis was associated with significantly less RAO compared to prolonged hemostasis. Rescue radial artery recanalization was effective in > 50%, but only in the short hemostasis group.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Arterial Occlusive Diseases* / diagnosis
  • Arterial Occlusive Diseases* / etiology
  • Arterial Occlusive Diseases* / prevention & control
  • Catheterization, Peripheral* / adverse effects
  • Catheterization, Peripheral* / methods
  • Duration of Therapy*
  • Female
  • Hemostatic Techniques* / standards
  • Hemostatic Techniques* / statistics & numerical data
  • Humans
  • Male
  • Middle Aged
  • Outcome Assessment, Health Care
  • Percutaneous Coronary Intervention* / adverse effects
  • Percutaneous Coronary Intervention* / methods
  • Plethysmography / methods
  • Radial Artery* / diagnostic imaging
  • Radial Artery* / pathology
  • Radial Artery* / surgery
  • Ulnar Artery / physiology
  • Ultrasonography, Doppler, Duplex / methods
  • Vascular Patency