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19 results

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Page 1
Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture.
HEALTH Investigators; Bhandari M, Einhorn TA, Guyatt G, Schemitsch EH, Zura RD, Sprague S, Frihagen F, Guerra-Farfán E, Kleinlugtenbelt YV, Poolman RW, Rangan A, Bzovsky S, Heels-Ansdell D, Thabane L, Walter SD, Devereaux PJ. HEALTH Investigators, et al. N Engl J Med. 2019 Dec 5;381(23):2199-2208. doi: 10.1056/NEJMoa1906190. Epub 2019 Sep 26. N Engl J Med. 2019. PMID: 31557429 Free article. Clinical Trial.
RESULTS: The primary end point occurred in 57 of 718 patients (7.9%) who were randomly assigned to total hip arthroplasty and 60 of 723 patients (8.3%) who were randomly assigned to hemiarthroplasty (hazard ratio, 0.95; 95% confidence interval [CI], 0.64 to 1.40; P = 0.79) …
RESULTS: The primary end point occurred in 57 of 718 patients (7.9%) who were randomly assigned to total hip arthroplasty and 60 of 723 pati …
Characterization of cerebrospinal fluid biomarkers associated with neurodegenerative diseases in healthy cynomolgus and rhesus macaque monkeys.
Robertson EL, Boehnke SE, Lyra E Silva NM, Armitage-Brown B, Winterborn A, Cook DJ, De Felice FG, Munoz DP. Robertson EL, et al. Alzheimers Dement (N Y). 2022 Apr 5;8(1):e12289. doi: 10.1002/trc2.12289. eCollection 2022. Alzheimers Dement (N Y). 2022. PMID: 35415210 Free PMC article.
NfL and t-tau were higher in males, and NfL was higher in rhesus macaques. p-tau was not affected by species or sex. We also examined whether sample location (lumbar or cisterna puncture) affected concentrations. ...
NfL and t-tau were higher in males, and NfL was higher in rhesus macaques. p-tau was not affected by species or sex. We also examined …
Factors Associated With Mortality After Surgical Management of Femoral Neck Fractures.
Bzovsky S, Comeau-Gauthier M, Schemitsch EH, Swiontkowski M, Heels-Ansdell D, Frihagen F, Bhandari M, Sprague S; FAITH Investigators; HEALTH Investigators. Bzovsky S, et al. J Orthop Trauma. 2020 Nov;34 Suppl 3:S15-S21. doi: 10.1097/BOT.0000000000001937. J Orthop Trauma. 2020. PMID: 33027161

RESULTS: Ninety-one (4.1%) and 304 (13.5%) of 2247 participants died within 90 days and 24 months of suffering a femoral neck fracture, respectively. Older age (P < 0.001), lower body mass index (P = 0.002), American Society of Anesthesiologists (ASA) class III/I

RESULTS: Ninety-one (4.1%) and 304 (13.5%) of 2247 participants died within 90 days and 24 months of suffering a femoral neck fracture, resp …
Validation of a novel risk score for severity of illness in acute exacerbations of COPD.
Shorr AF, Sun X, Johannes RS, Yaitanes A, Tabak YP. Shorr AF, et al. Chest. 2011 Nov;140(5):1177-1183. doi: 10.1378/chest.10-3035. Epub 2011 Apr 28. Chest. 2011. PMID: 21527510

Mortality increased with increasing BAP-65 class, ranging from < 1% in subjects in class I (score of 0) to > 25% in those meeting all BAP-65 criteria (Cochran-Armitage trend test z = -38.48, P < .001). The need for MV also increased with escalating score (2

Mortality increased with increasing BAP-65 class, ranging from < 1% in subjects in class I (score of 0) to > 25% in those meeting all

Revascularization versus medical therapy for renal-artery stenosis.
ASTRAL Investigators; Wheatley K, Ives N, Gray R, Kalra PA, Moss JG, Baigent C, Carr S, Chalmers N, Eadington D, Hamilton G, Lipkin G, Nicholson A, Scoble J. ASTRAL Investigators, et al. N Engl J Med. 2009 Nov 12;361(20):1953-62. doi: 10.1056/NEJMoa0905368. N Engl J Med. 2009. PMID: 19907042 Free article. Clinical Trial.
RESULTS: During a 5-year period, the rate of progression of renal impairment (as shown by the slope of the reciprocal of the serum creatinine level) was -0.07x10(-3) liters per micromole per year in the revascularization group, as compared with -0.13x10(-3) liters per micromole p …
RESULTS: During a 5-year period, the rate of progression of renal impairment (as shown by the slope of the reciprocal of the serum creatinin …
Cerebral vasospasm in patients with traumatic subarachnoid hemorrhage, a possible point of intervention?
Ernst G, Hughes K, Andrews B, Bauer A. Ernst G, et al. J Clin Neurosci. 2024 May 18;125:106-109. doi: 10.1016/j.jocn.2024.05.009. Online ahead of print. J Clin Neurosci. 2024. PMID: 38763077

Traumatic vasospasm was associated with higher-grade TBI based on Cochran-Armitage trend test (p < 0.05). Vasospasm patients had longer length of stay in the ICU (mean days 13.64 vs 7.24, P < 0.001), and had a higher incidence of death (39.29 % vs 20.81

Traumatic vasospasm was associated with higher-grade TBI based on Cochran-Armitage trend test (p < 0.05). Vasospasm patient

Predictors of Loss to Follow-up in Hip Fracture Trials: A Secondary Analysis of the FAITH and HEALTH Trials.
Sivaratnam S, Comeau-Gauthier M, Sprague S, Schemitsch EH, Poolman RW, Frihagen F, Bhandari M, Swiontkowski M, Bzovsky S; FAITH Investigators; HEALTH Investigators. Sivaratnam S, et al. J Orthop Trauma. 2020 Nov;34 Suppl 3:S22-S28. doi: 10.1097/BOT.0000000000001928. J Orthop Trauma. 2020. PMID: 33027162

Being non-White (P = 0.003), enrolled from a non-European hospital (P < 0.001), and treated with arthroplasty (P < 0.001) were associated with an increased odds of not completing the 24-month follow-up visit. Being enrolled from a hospital in the United

Being non-White (P = 0.003), enrolled from a non-European hospital (P < 0.001), and treated with arthroplasty (P &lt

19 results