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Page 1
N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases.
Kaya C, Konstantinović J, Kany AM, Andreas A, Kramer JS, Brunst S, Weizel L, Rotter MJ, Frank D, Yahiaoui S, Müller R, Hartmann RW, Haupenthal J, Proschak E, Wichelhaus TA, Hirsch AKH. Kaya C, et al. Among authors: kany am. J Med Chem. 2022 Mar 10;65(5):3913-3922. doi: 10.1021/acs.jmedchem.1c01755. Epub 2022 Feb 21. J Med Chem. 2022. PMID: 35188771
The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection.
Bublitz A, Brauer M, Wagner S, Hofer W, Müsken M, Deschner F, Lesker TR, Neumann-Schaal M, Paul LS, Nübel U, Bartel J, Kany AM, Zühlke D, Bernecker S, Jansen R, Sievers S, Riedel K, Herrmann J, Müller R, Fuchs TM, Strowig T. Bublitz A, et al. Among authors: kany am. Cell Host Microbe. 2023 May 10;31(5):734-750.e8. doi: 10.1016/j.chom.2023.04.003. Epub 2023 Apr 24. Cell Host Microbe. 2023. PMID: 37098342 Free article.
Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors.
Kaya C, Walter I, Yahiaoui S, Sikandar A, Alhayek A, Konstantinović J, Kany AM, Haupenthal J, Köhnke J, Hartmann RW, Hirsch AKH. Kaya C, et al. Among authors: kany am. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112295. doi: 10.1002/anie.202112295. Epub 2021 Dec 13. Angew Chem Int Ed Engl. 2022. PMID: 34762767 Free PMC article.
N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases.
Konstantinović J, Yahiaoui S, Alhayek A, Haupenthal J, Schönauer E, Andreas A, Kany AM, Müller R, Koehnke J, Berger FK, Bischoff M, Hartmann RW, Brandstetter H, Hirsch AKH. Konstantinović J, et al. Among authors: kany am. J Med Chem. 2020 Aug 13;63(15):8359-8368. doi: 10.1021/acs.jmedchem.0c00584. Epub 2020 Jun 17. J Med Chem. 2020. PMID: 32470298 Free PMC article.
22 results